Evidence map›Paper›PMID 28553202›Full record

ArticleFrontiers in molecular neuroscience2017

A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission in

Mei Han, Wenjuan Zou, Hao Chang, Yong Yu, Haining Zhang, Shitian Li, Hankui Cheng, Guifeng Wei, Yan Chen, Valerie Reinke and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mei HanKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of MedicineHangzhou, China.
Wenjuan ZouKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of MedicineHangzhou, China.
Hao ChangNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Yong YuNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Haining ZhangNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Shitian LiKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of MedicineHangzhou, China.
Hankui ChengKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of MedicineHangzhou, China.
Guifeng WeiNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Yan ChenNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Valerie ReinkeDepartment of Genetics, Yale University School of MedicineNew Haven, CT, USA.
Tao XuNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesBeijing, China.
Lijun KangKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of MedicineHangzhou, China.
Zhejiang University · CNInstitute of Biophysics · CNChinese Academy of Sciences · CNYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analysis and Sorter (COPAS) to monitor the fluorescence of synapto-pHluorin (SpH), we performed a whole-genome RNAi screen in

Indexed as

C2H2 zinc-finger proteinC. elegansRNAi screensynaptic transmissionsynaptic vesicles

Identifiers

PMID28553202
PMCPMC5425591
OpenAlexW2610899736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.