ArticleFrontiers in neuroscience2017
A Resilient, Non-neuronal Source of the Spatiotemporal Lag Structure Detected by BOLD Signal-Based Blood Flow Tracking.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum.Schizophrenia (Heidelberg, Germany) · 2026Article
- Large-Vessel Venous Signal Confounds Apparent Amygdala Activation in BOLD fMRI.bioRxiv : the preprint server for biology · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- Systemic physiological "noise" in fMRI has clinical relevance.medRxiv : the preprint server for health sciences · 2025Article
- Brain-wide functional connectivity artifactually inflates throughout functional magnetic resonance imaging scans.Nature human behaviour · 2024Article
- Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network.Psychiatry and clinical neurosciences · 2024Article
- Hemodynamic timing in resting-state and breathing-task BOLD fMRI.NeuroImage · 2023Article
- Reproducibility of cerebral perfusion measurements using BOLD delay.Human brain mapping · 2023Article
- Spatial variation of changes in test-retest reliability of functional connectivity after global signal regression: The effect of considering hemodynamic delay.Human brain mapping · 2023Article
- Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Blood Oxygen Level-Dependent Lag Patterns Differ Between Rest and Task Conditions, but Are Largely Typical in Autism.Brain connectivity · 2022Article
- A novel approach for assessing hypoperfusion in stroke using spatial independent component analysis of resting-state fMRI.Human brain mapping · 2021Article
- The relationship between attention and avoidance coping in anorexia nervosa: functional magnetic resonance imaging study.BJPsych open · 2021Article
- Effects of Thresholding on Voxel-Wise Correspondence of Breath-Hold and Resting-State Maps of Cerebrovascular Reactivity.Frontiers in neuroscience · 2021Article
- The Acute Effects of Time-Varying Caloric Vestibular Stimulation as Assessed With fMRI.Frontiers in systems neuroscience · 2021Article
- Dynamic time warping outperforms Pearson correlation in detecting atypical functional connectivity in autism spectrum disorders.NeuroImage · 2020Article
- A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing.Brain : a journal of neurology · 2020Article
- Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Article
- Low Frequency Systemic Hemodynamic "Noise" in Resting State BOLD fMRI: Characteristics, Causes, Implications, Mitigation Strategies, and Applications.Frontiers in neuroscience · 2019Review
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4 authors.
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Abstract
Recent evidence has suggested that blood oxygenation level-dependent (BOLD) signals convey information about brain circulation via low frequency oscillation of systemic origin (sLFO) that travels through the vascular structure ("lag mapping"). Prompted by its promising application in both physiology and pathology, we examined this signal component using multiple approaches. A total of 30 healthy volunteers were recruited to perform two reproducibility experiments at 3 Tesla using multiband echo planar imaging. The first experiment investigated the effect of denoising and the second was designed to study the effect of subject behavior on lag mapping. The lag map's intersession test-retest reproducibility and image contrast were both diminished by removal of either the neuronal or the non-neuronal (e.g., cardiac, respiratory) components by independent component analysis-based denoising, suggesting that the neurovascular coupling also comprises a part of the BOLD lag structure. The lag maps were, at the same time, robust against local perfusion increases due to visuomotor task and global changes in perfusion induced by breath-holding at the same level as the intrasession reliability. The lag structure was preserved after time-locked averaging to the visuomotor task and breath-holding events, while any preceding signal changes were canceled out for the visuomotor task, consistent with the passive effect of neurovascular coupling in the venous side of the vasculature. These findings support the current assumption that lag mapping primarily reflects vascular structure despite the presence of sLFO perturbation of neuronal or non-neuronal origin and, thus, emphasize the vascular origin of the lag map, encouraging application of BOLD-based blood flow tracking.
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