Evidence map›Paper›PMID 28553105›Full record

ArticleInternational journal of nanomedicine2017

Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach.

Shaofeng Lou, Xiuyuan Zhang, Mingming Zhang, Shenglu Ji, Weiwei Wang, Ju Zhang, Chen Li, Deling Kong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Drug delivery · 2021
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shaofeng LouKey Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University.
Xiuyuan ZhangTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin, People's Republic of China.
Mingming ZhangTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin, People's Republic of China.
Shenglu JiKey Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University.
Weiwei WangTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin, People's Republic of China.
Ju ZhangKey Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University.
Chen LiTianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin, People's Republic of China.
Deling KongKey Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University.
Nankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A reductase-cleavable and thermo-responsive star-shaped polymer nanogel was prepared via an "arm-first" atom transfer radical polymerization approach. The nanogel consists of a thermo- and redox-sensitive core and a zwitterionic copolymer block. The dual sensitive core is composed of poly(N-isopropylacrylamide) that is formed by disulfide crosslinking of N-isopropylacrylamide. The zwitterionic copolymer block contains a poly(sulfobetaine methacrylate) component, a known anti-adsorptive moiety that extends blood circulation time, and a lactose motif of poly(2-lactobionamidoethyl methacrylamide) that specifically targets the asialoglycoprotein receptors (ASGP-Rs) of hepatoma. Doxorubicin (DOX) was encapsulated into the cross-linked nanogels via solvent extraction/evaporation method and dialysis; average diameter of both blank and DOX-loaded nanogels was ~120 nm. The multi-responsiveness of nanogel drug release in different temperatures and redox conditions was assessed. After 24 h, DOX release was only ~20% at 30°C with 0 mM glutathione (GSH), whereas over 90% DOX release was observed at 40°C and 10 mM GSH, evidence of dual responsiveness to temperature and reductase GSH. The IC

Indexed as

Acrylic ResinsAntibiotics, AntineoplasticAsialoglycoprotein ReceptorCarcinoma, HepatocellularDoxorubicinDrug Delivery SystemsDrug LiberationHeLa CellsHep G2 CellsHumansLactoseLiver NeoplasmsMagnetic Resonance SpectroscopyMicroscopy, Electron, TransmissionMolecular Targeted TherapyNanogelsAcrylic ResinsAntibiotics, AntineoplasticAsialoglycoprotein ReceptorDoxorubicinLactoseNanogelspoly(2-lactobionamidoethyl methacrylamide)polyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneiminePolymethacrylic Acidspoly-N-isopropylacrylamidearm-first ATRPdrug deliveryglycopolymerhepatoma targetingmulti-responsive nanogel

Identifiers

PMID28553105
PMCPMC5439995
OpenAlexW2614048402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.