ArticleInternational journal of chronic obstructive pulmonary disease2017
Pulmonary artery to aorta ratio is associated with cardiac structure and functional changes in mild-to-moderate COPD.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Tricuspid annular plane systolic excursion (TAPSE) in chronic obstructive pulmonary disease patients: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2025Pooled it
- Relationship of Pulmonary Artery to Aorta Ratio With Pulmonary Vascular Resistance, Compliance, and Outcomes in COPD and Interstitial Lung Disease in PVDOMICS.Pulmonary circulation · 2026Article
- Risk Factors for Acute Exacerbation in Patients with COPD Group E in Ningbo: Risk Analysis of Irregular Review, Cardiovascular Complications, and Lung Function Decline.International journal of chronic obstructive pulmonary disease · 2025Article
- The clinical characteristics associated with the ratio between the main pulmonary artery and ascending aorta diameter in patients with acute exacerbation of chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- The impact of pulmonary artery to ascending aorta diameter ratio progression on the prognosis of NSCLC patients treated with immune checkpoint inhibitors.Frontiers in immunology · 2024Article
- Diagnosis of COVID-19 with simultaneous accurate prediction of cardiac abnormalities from chest computed tomographic images.PloS one · 2023Article
- Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Diagnostic accuracy, sensitivity, and specificity of CT pulmonary artery to aorta diameter ratio in screening for pulmonary hypertension in end-stage COPD patients.Croatian medical journal · 2021Article
- The ratio of main pulmonary artery to ascending aorta diameter is associated with the right ventricular outflow tract ventriculararrhythmias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Pulmonary artery to ascending aorta ratio by echocardiography: A strong predictor for presence and severity of pulmonary hypertension.PloS one · 2020Article
- Assessing pulmonary hypertension in COPD. Is there a role for computed tomography?International journal of chronic obstructive pulmonary disease · 2019Review
- Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-Blocker Therapy in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2017Article
- Advances in Chronic Obstructive Pulmonary Disease Imaging.Barcelona respiratory network reviewsArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe ratio of the diameter of the pulmonary artery (PA) to the diameter of the aorta (PA:A) on computed tomography (CT) imaging is associated with both COPD exacerbation and pulmonary hypertension. The mechanisms of PA enlargement in COPD are poorly understood.
methodsIn this retrospective, single center study we evaluated pulmonary function, CT scans, right heart catheterizations, and echocardiography in 88 subjects with mild-to-moderately severe COPD. A sensitivity analysis was performed in 43 subjects in whom CT scan and echocardiogram were performed within 50 days of each other. To evaluate the association between PA:A ratio and echocardiographic parameters and hemodynamics, we performed simple correlations and multivariable linear regression analysis adjusting for lung function, age, sex, race, and diastolic function.
resultsAll subjects had preserved left ventricular (LV) systolic function (LV ejection fraction 62.7%±5.5%). Among them, 56.8% had evidence of diastolic dysfunction. There was no association between PA:A ratio and the presence of diastolic dysfunction. In a multivariable model, PA:A ratio was associated with right ventricular (RV) chamber size (β=0.015;
conclusionIn patients with mild-to-moderately severe COPD and preserved LV function, increased PA:A ratio occurs independent of LV diastolic dysfunction. Furthermore, the PA:A ratio is associated with right heart structure and function changes, as well as pulmonary hemodynamics. These findings indicate that PA:A ratio is a marker of intrinsic pulmonary vascular changes rather than impaired LV filling.
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