ArticlePloS one2017
Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
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- C17:0, rather than C15:0, drives the protective association of odd-chain saturated fatty acids with metabolic syndrome: mediation and joint effect evidence.European journal of nutrition · 2025Article
- Impact of glucose and propionic acid on even and odd chain fatty acid profiles of oleaginous yeasts.BMC microbiology · 2025Article
- Spontaneous Formation of Micelles and Vesicles in Langmuir Monolayers of Heneicosanoic Acid.ACS omega · 2025Article
- Dietary habits and plasma lipid concentrations in a general Japanese population.Metabolomics : Official journal of the Metabolomic Society · 2024Article
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- Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years.Journal of inflammation research · 2024Article
- Whole-Milk Dairy Foods: Biological Mechanisms Underlying Beneficial Effects on Risk Markers for Cardiometabolic Health.Advances in nutrition (Bethesda, Md.) · 2023Review
- Article
- Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case-cohort study.Diabetologia · 2023Article
- The Effect of Feeding Laying Hens with Nonindustrial Hemp Seed on the Fatty Acid Profile, Cholesterol Level, and Tocopherol Composition of Egg Yolk.International journal of food science · 2023Article
- Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry-based semi-target lipidomic analysis.Journal of diabetes investigation · 2023Observational
- Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Article
- Beetroot juice - a suitable post-marathon metabolic recovery supplement?Journal of the International Society of Sports Nutrition · 2021Review
- Milk Odd and Branched Chain Fatty Acids in Dairy Cows: A Review on Dietary Factors and Its Consequences on Human Health.Animals : an open access journal from MDPI · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSaturated fatty acids are generally thought to have detrimental effects on health. However, a recent study showed that even- and odd-chain saturated fatty acids had opposite associations with type 2 diabetes. Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism.
objectiveWe examined the associations of saturated fatty acids in serum phospholipids with circulating levels of adipokines among a Japanese population.
designA cross-sectional study was conducted among 484 Japanese employees (284 men and 200 women) aged 20-65 years. The serum fatty acid composition in the phospholipid fraction was measured by gas-chromatography. Serum leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), resistin, and visfatin were measured using a Luminex suspension bead-based multiplexed array. Multiple linear regression analysis was performed to assess the association between saturated fatty acids and adipokines, with adjustment for potential confounding variables.
resultsEven- and odd-chain saturated fatty acids were differentially associated with adipokines. Higher levels of even-chain saturated fatty acids (14:0 myristic, 16:0 palmitic, and 18:0 stearic acids) were associated with higher levels of resistin (P for trend = 0.048) and lower levels of adiponectin (P for trend = 0.003). By contrast, odd-chain saturated fatty acids (15:0 pentadecanoic and 17:0 heptadecanoic acids) showed inverse associations with leptin and PAI-1 (P for trend = 0.048 and 0.02, respectively). Visfatin was positively associated with both even- and odd-chain saturated fatty acids.
conclusionsThe results suggest that even- and odd-chain saturated fatty acids are differentially associated with adipokine profile.
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