Observational studyExperimental gerontology2017
Leisure-time physical activity and leukocyte telomere length among older women.
Observational study in Experimental gerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The relationship between physical activity and telomere length in women: A systematic review.Mechanisms of ageing and development · 2025Pooled it
- Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review.Sports medicine - open · 2022Pooled it
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Obstetric and urogynecological history are associated with lower limb strength and physical performance in middle-age and older women: a community-based cross-sectional study.BMC women's health · 2026Observational
- Exploring Chronic Pain, Immune Dysfunction and Lifestyle: A Focus on T Cell Exhaustion and Senescence.Biomolecules · 2025Review
- Roles of benefit finding in psychological and inflammatory adjustments in persons with colorectal cancer: a prospective analysis on the multidimensionality of benefit finding.Psychology & health · 2025Article
- Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length.Current nutrition reports · 2024Review
- Associations between objectively measured overall and intensity-specific physical activity and phase angle in older adults.Scientific reports · 2024Article
- Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno-/GrimAge and DNA-methylation based PAI1.GeroScience · 2024Article
- Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study.PloS one · 2024Article
- Time Spent Jogging/Running and Biological Aging in 4458 U.S. Adults: An NHANES Investigation.International journal of environmental research and public health · 2023Article
- Associations of sleeping, sedentary and physical activity with phenotypic age acceleration: a cross-sectional isotemporal substitution model.BMC geriatrics · 2023Article
- Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.Journal of clinical medicine · 2021Review
- Effects of Physical Exercise on Cognition and Telomere Length in Healthy Older Women.Brain sciences · 2021Article
- Telomere length and its relationships with lifestyle and behavioural factors: variations by sex and race/ethnicity.Age and ageing · 2021Article
- Vitamin D Deficiency and Risk of Metabolic Syndrome in Aging Men.The world journal of men's health · 2021Review
- Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke.Frontiers in aging neuroscience · 2021Article
- Hazardous air pollutants and telomere length in the Sister Study.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Association of Physical Activity With Telomere Length Among Elderly Adults - The Oulu Cohort 1945.Frontiers in physiology · 2019Article
- Telomeres, Aging and Exercise: Guilty by Association?International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundShortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults.
methodsIn this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study. Self-reported physical activity was assessed by questionnaire, and LTL was measured by Southern blot. The association between physical activity and LTL was evaluated using multiple linear regression models adjusted for demographic characteristics, lifestyle behaviors, and health-related variables.
resultsWomen were on average aged 79.2 (standard deviation 6.7) years old. In the final model adjusted for age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was on average 110 (95% confidence interval, 20-190) base pairs longer among women in the highest (≥17.00MET-hours/week) compared with the lowest (<1.25MET-hours/week) level of total leisure-time physical activity (P for trend=0.02). Higher levels of moderate-to-vigorous physical activity (P for trend=0.04) and faster walking speed (P for trend=0.03) were also associated with longer LTL in the fully-adjusted models.
conclusionOlder women participating in greater amounts of total leisure-time physical activity and moderate-to-vigorous physical activity had longer LTL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.