ArticleBehavioural brain research2017
Altered reward sensitivity in female offspring of cocaine-exposed fathers.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Transgenerational memory deficits in cocaine-sired male rat offspring and grand-offspring.Addiction neuroscience · 2026Article
- PGx-BasedCurrent neuropharmacology · 2026Article
- Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences.Biology · 2025Review
- Extended abstinence from morphine alters sperm smRNA expression and prevents transmission of intergenerational phenotypes.Environmental epigenetics · 2025Article
- Persisting neurobehavioral consequences of daily or intermittent paternal cannabis administration in F1 and F2 Rats.Neurotoxicology · 2024Article
- An overview of the methamphetamine effect on male sexual behavior and reproductive system.Physiological research · 2023Review
- Sex-dependent fear memory impairment in cocaine-sired rat offspring.Science advances · 2023Article
- Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk.Psychopharmacology · 2023Article
- Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry.Trends in neurosciences · 2022Review
- Cocaine-Induced Changes in SpermThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Paternal Cocaine in Mice Alters Social Behavior and Brain Oxytocin Receptor Density in First Generation Offspring.Neuroscience · 2022Article
- Does paternal methamphetamine exposure affect the behavior of rat offspring during development and in adulthood?Physiological research · 2021Article
- Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies.Scientific reports · 2021Article
- Exposure to drugs of abuse induce effects that persist across generations.International review of neurobiology · 2021Article
- Paternal morphine self-administration produces object recognition memory deficits in female, but not male offspring.Psychopharmacology · 2020Article
- Paternal morphine exposure induces bidirectional effects on cocaine versus opioid self-administration.Neuropharmacology · 2020Article
- Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring.Psychopharmacology · 2019Article
- Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Review
- Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.The European journal of neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Recent rodent studies have demonstrated that parental cocaine exposure can influence offspring behavior, supporting the idea that environmental insults can impact subsequent generations. However, studies on the effects of paternal cocaine exposure are limited and multiple inconsistencies exist. In the current study, we behaviorally characterize the effects of paternal cocaine exposure in a C57BL/6J intergenerational mouse model. Male sires were administered cocaine hydrochloride (20mg/kg) or saline (0.01mL/g) once a day for 75days, and bred with drug naïve females twenty-four hours after the final injection. Offspring, separated by sex, were tested in a battery of behaviors. We found that paternal cocaine exposure altered sensitivity to the rewarding and stimulant effects of psychostimulants and natural reward (sucrose) in female offspring; female cocaine-sired offspring showed blunted cocaine preference using cocaine conditioned place preference (CPP) at a low dose (5mg/kg), but displayed similar preference at a higher dose (10mg/kg) compared to saline-sired controls. Additionally, cocaine-sired female offspring exhibited higher psychomotor sensitivity to cocaine (10mg/kg) and amphetamine (2mg/kg) and consumed more sucrose. Cocaine-sired males exhibited increased psychomotor effects of cocaine and amphetamine. Male offspring also displayed an anxiety-like phenotype. No effect of paternal cocaine exposure was observed on depressive-like, learning and memory or social behavior in male or female offspring. Collectively, our findings show that paternal, chronic cocaine exposure induces intergenerational behavioral effects in male and female offspring with greatest impact on sensitivity to psychostimulants and sucrose in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.