Evidence map›Paper›PMID 28552576›Full record

ArticleStructure (London, England : 1993)2017

TomoMiner and TomoMinerCloud: A Software Platform for Large-Scale Subtomogram Structural Analysis.

Zachary Frazier, Min Xu, Frank Alber

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Computational methods forFrontiers in cellular and infection microbiology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Image-derived generative modeling of pseudo-macromolecular structures - towards the statistical assessment of Electron CryoTomography template matching.BMVC : proceedings of the British Machine Vision Conference. British Machine Vision Conference · 2018
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zachary FrazierMolecular and Computational Biology, Department of Biological Sciences, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089, USA.
Min XuComputational Biology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address: mxu1@cs.cmu.edu.
Frank AlberMolecular and Computational Biology, Department of Biological Sciences, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089, USA. Electronic address: alber@usc.edu.

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Computational Methods Towards the Spatio-Temporal Organization of the ProteomeR01GM096089 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALBER, FRANK · 2011 to 2015
$1.6M
NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM096089
6 · The paper itself

Abstract

Cryo-electron tomography (cryo-ET) captures the 3D electron density distribution of macromolecular complexes in close to native state. With the rapid advance of cryo-ET acquisition technologies, it is possible to generate large numbers (>100,000) of subtomograms, each containing a macromolecular complex. Often, these subtomograms represent a heterogeneous sample due to variations in the structure and composition of a complex in situ form or because particles are a mixture of different complexes. In this case subtomograms must be classified. However, classification of large numbers of subtomograms is a time-intensive task and often a limiting bottleneck. This paper introduces an open source software platform, TomoMiner, for large-scale subtomogram classification, template matching, subtomogram averaging, and alignment. Its scalable and robust parallel processing allows efficient classification of tens to hundreds of thousands of subtomograms. In addition, TomoMiner provides a pre-configured TomoMinerCloud computing service permitting users without sufficient computing resources instant access to TomoMiners high-performance features.

Indexed as

SoftwareChaperonin 10Chaperonin 60Cloud ComputingClusterinElectron Microscope TomographyImage Processing, Computer-AssistedChaperonin 10Chaperonin 60Clusterincloud computingcryo-electron tomographydistributed computingfast rotational matchingsubtomogram alignmentsubtomogram classification

Identifiers

PMID28552576
PMCPMC5567730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.