ArticleJournal of neuroscience methods2018
The rabbit as a behavioral model system for magnetic resonance imaging.
Article in Journal of neuroscience methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Animal models of neuropsychiatric systemic lupus erythematosus: deciphering the complexity and guiding therapeutic development.Autoimmunity · 2024Review
- Central nodes of canine functional brain networks are concentrated in the cingulate gyrus.Brain structure & function · 2023Article
- Diet-induced Alzheimer's-like syndrome in the rabbit.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- Brain activity studied with magnetic resonance imaging in awake rabbits.Frontiers in neuroimaging · 2022Review
- Detection of memory- and learning-related brain connectivity changes following trace eyeblink-conditioning using resting-state functional magnetic resonance imaging in the awake rabbit.The Journal of comparative neurology · 2021Article
- Development of a simple method for differential delivery of volatile anesthetics to the spinal cord of the rabbit.PloS one · 2020Article
- Aβ oligomer induced cognitive impairment and evaluation of ACU193-MNS-based MRI in rabbit.Alzheimer's & dementia (New York, N. Y.) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundfMRI requires that subjects not move during image acquisition. This has been achieved by instructing people not to move, or by anesthetizing experimental animal subjects to induce immobility. We have demonstrated that a surgically implanted headbolt onto the skull of a rabbit allows their brain to be imaged comfortably while the animal is awake. This article provides a detailed method for the preparation. NEW
methodWe took advantage of the rabbit's tolerance for restraint to image the brain while holding the head at the standard stereotaxic angle. Visual stimulation was produced by flashing green LEDs and whisker stimulation was done by powering a small coil of wire attached to a fiber band. Blinking was recorded with an infrared emitter/detector directed at the eye with fiber-optic cabling.
resultsResults indicate that a single daily session of habituation is sufficient to produce adequate immobility on subsequent days to avoid movement artifacts. Results include high resolution images in the stereotaxic plane of the rabbit. COMPARISON WITH EXISTING METHOD(S): We see no degradation or distortion of MR signal, and the headbolt provides a means for rapid realignment of the head in the magnet from day to day, and across subjects. The use of rabbits instead of rodents allows much shorter periods of habituation, and the rabbit allows behavior to be observed during the day while the animal is in its normal wake cycle.
conclusionsThe natural tolerance of the rabbit for restraint makes it a valuable subject for MRI studies of the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.