ArticleCurrent biology : CB2017
Modular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 1 of them a synthesis that pooled it.
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Who cites it
218 citing papers in PubMed, 1 synthesis or guideline pooled it, 417 citations in OpenAlex.
- The developmental trajectories of working memory updating from early childhood to adolescence: A meta-analysis.British journal of psychology (London, England : 1953) · 2026Pooled it
- The local properties of bold signal fluctuations at rest monitor inhibitory control training in adolescents.Developmental cognitive neuroscience · 2019Trial
- Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder.Translational psychiatry · 2018Trial
- Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation.iScience · 2026Article
- Executive functions as a transdiagnostic endophenotype in developmental psychopathology.Molecular psychiatry · 2026Review
- What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Auditory Speech Processing Efficiency: Functional Connectivity Graph Theory Analysis of Lexical Processing Effort.bioRxiv : the preprint server for biology · 2026Article
- Neural focalization of dorsolateral prefrontal cortex and the inferior parietal lobule is associated with inhibitory control performance in adolescence.Developmental cognitive neuroscience · 2026Article
- Demographics change the relationships between socioeconomic status, white matter network organization, and cognition in children.Developmental cognitive neuroscience · 2026Article
- Linking temporal dynamics of children's natural behavior to brain development.Developmental cognitive neuroscience · 2026Article
- Robust probabilistic measurement of structural-functional module consistency in infant brain development.Brain structure & function · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Prediction modeling in transdiagnostic risk: results from the PROCAN study.Brain imaging and behavior · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Longitudinal Study of Adolescent Brain Connectivity Development Using Sign-Aware Graph Theory Metrics.Human brain mapping · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Large-sample PCA eigenvectors stabilize cortical thickness components and improve small sample brain behavior prediction.Scientific reports · 2026Article
158 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
The human brain is organized into large-scale functional modules that have been shown to evolve in childhood and adolescence. However, it remains unknown whether the underlying white matter architecture is similarly refined during development, potentially allowing for improvements in executive function. In a sample of 882 participants (ages 8-22) who underwent diffusion imaging as part of the Philadelphia Neurodevelopmental Cohort, we demonstrate that structural network modules become more segregated with age, with weaker connections between modules and stronger connections within modules. Evolving modular topology facilitates global network efficiency and is driven by age-related strengthening of hub edges present both within and between modules. Critically, both modular segregation and network efficiency are associated with enhanced executive performance and mediate the improvement of executive functioning with age. Together, results delineate a process of structural network maturation that supports executive function in youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.