ArticleCurrent biology : CB2017
A Mechanistic Link from GABA to Cortical Architecture and Perception.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- GABA concentrations in the anterior temporal lobe predict human semantic processing.Scientific reports · 2017Trial
- Quantitative susceptibility mapping and MRS-based multimodal machine learning for early Parkinson's disease classification.NPJ Parkinson's disease · 2026Article
- Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Human motor cortical gamma activity relates to GABAergic intracortical inhibition and motor learning.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Baclofen, a GABAb receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Recurrent inhibition refines mental templates to optimize perceptual decisions.Science advances · 2024Article
- GABAergic inhibition shapes behavior and neural dynamics in human visual working memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Unveiling MRI markers for Parkinson's Disease: GABAergic dysfunction and cortical changes.NeuroImage. Clinical · 2024Article
- Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome.Brain sciences · 2023Article
- Article
- Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex.Nature communications · 2023Article
- On the Homology of the Dominant and Non-Dominant Corticospinal Tracts: A Novel Neurophysiological Assessment.Brain sciences · 2023Article
- Effective Intracerebral Connectivity in Acute Stroke: A TMS-EEG Study.Brain sciences · 2023Article
- Quantitative GABA magnetic resonance spectroscopy as a measure of motor learning function in the motor cortex after subarachnoid hemorrhage.Frontiers in neurology · 2023Article
- Functional balance at rest of hemispheric homologs assessed via normalized compression distance.Frontiers in neuroscience · 2023Article
- Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Effect of cortical extracellular GABA on motor response.Journal of computational neuroscience · 2022Article
- The effect of parietal glutamate/GABA balance on test anxiety levels in early childhood in a cross-sectional and longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The differential association between local neurotransmitter levels and whole-brain resting-state functional connectivity in two distinct cingulate cortex subregions.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Understanding both the organization of the human cortex and its relation to the performance of distinct functions is fundamental in neuroscience. The primary sensory cortices display topographic organization, whereby receptive fields follow a characteristic pattern, from tonotopy to retinotopy to somatotopy [1]. GABAergic signaling is vital to the maintenance of cortical receptive fields [2]; however, it is unclear how this fine-grain inhibition relates to measurable patterns of perception [3, 4]. Based on perceptual changes following perturbation of the GABAergic system, it is conceivable that the resting level of cortical GABAergic tone directly relates to the spatial specificity of activation in response to a given input [5-7]. The specificity of cortical activation can be considered in terms of cortical tuning: greater cortical tuning yields more localized recruitment of cortical territory in response to a given input. We applied a combination of fMRI, MR spectroscopy, and psychophysics to substantiate the link between the cortical neurochemical milieu, the tuning of cortical activity, and variability in perceptual acuity, using human somatosensory cortex as a model. We provide data that explain human perceptual acuity in terms of both the underlying cellular and metabolic processes. Specifically, higher concentrations of sensorimotor GABA are associated with more selective cortical tuning, which in turn is associated with enhanced perception. These results show anatomical and neurochemical specificity and are replicated in an independent cohort. The mechanistic link from neurochemistry to perception provides a vital step in understanding population variability in sensory behavior, informing metabolic therapeutic interventions to restore perceptual abilities clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.