ArticleCell2017
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Open access · greenAbstract read
In one paragraph
Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 401 papers.
0numbers the graph read from it
0cells of the map it votes in
401citing papers in PubMed
69.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
401 citing papers in PubMed, 644 citations in OpenAlex.
- Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS.Journal of neuroinflammation · 2026Trial
- Dynamics of Spinal Fluid Immune Cell Alterations Following Cladribine Tablet Treatment in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2026Trial
- Studying Hair Growth in Mice: Synchronization of Hair Follicle Growth by Depilation.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research.Signal transduction and targeted therapy · 2026Review
- Beyond immune suppression: regenerative programs in regulatory T cells.Cell insight · 2026Review
- Hair Follicle Stem Cells: Emerging Physiology and Therapeutic Applications.Stem cell reviews and reports · 2026Review
- Regulatory T cells: From Foxp3 to tolerance-inducing therapies.The Journal of investigative dermatology · 2026Review
- A two-hit mechanism triggers autoimmune hair loss.Nature · 2026Article
- Single-Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age-Associated Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT.The American Journal of dermatopathology · 2026Review
- Review
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.Research square · 2026Article
- Mucosal-associated invariant T cells support IL-15-dependent Treg response in skin injury and promote resolution of skin inflammation.bioRxiv : the preprint server for biology · 2026Article
- Human tissue-resident CD8 T cells contribute to trophoblast homeostasis in health and during acute inflammation.bioRxiv : the preprint server for biology · 2026Article
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- In vitro and in vivo models for androgenetic alopecia drug development.Disease models & mechanisms · 2026Review
- Immunopathogenesis and Experimental Models of Alopecia Areata: From Mechanistic Insights to Translational Platforms.Clinical reviews in allergy & immunology · 2026Review
341 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byT2017
- Commented on by
- Commented on by
Authors and funding
21 authors at 5 institutions in 3 countries.
Niwa AliDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Bahar ZirakDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Robert Sanchez RodriguezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Mariela L PauliDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Hong-An TruongDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kevin LaiDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Richard AhnDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Kaitlin CorbinDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Margaret M LoweDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Tiffany C ScharschmidtDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Keyon TaravatiDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Madeleine R TanDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Roberto R Ricardo-GonzalezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Audrey NosbaumDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Marta BertoliniDepartment of Dermatology, University of Muenster, 48149 Muenster, Germany.
Wilson LiaoDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Frank O NestleCutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
Ralf PausCentre for Dermatological Research, University of Manchester & NIHR Manchester Biomedical Research Centre, Manchester M13 9PL, UK.
George CotsarelisDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abul K AbbasDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: michael.rosenblum@ucsf.edu.
University of California, San Francisco · USKing's College London · GBNIHR Manchester Biomedical Research Centre · GBUniversity of Münster · DEUniversity of Pennsylvania · US
Funding
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MHair Follicle Neogenesis in Response to WoundingR01AR055309 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI COTSARELIS, GEORGE · 2007 to 2017
$3.5MMHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5MFunctional Manipulation of Memory Regulatory T cells in SkinDP2AR068130 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2014 to 2014
$2.4MElucidating mechanisms of tolerance to commensal skin bacteriaK08AR068409 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHARSCHMIDT, TIFFANY CRAWFORD · 2015 to 2019
$851kMechanisms of immune regulation in the skinK08AR062064 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2012 to 2016
$670kElucidating the Fundamental Biology of Memory Regulatory T cells in SkinR21AR066821 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2014 to 2015
$381kNCI NIH HHS P30 CA082103NIAID NIH HHS T32 AI007334NIAID NIH HHS U01 AI119125NIAMS NIH HHS DP2 AR068130NIAMS NIH HHS K08 AR062064NIAMS NIH HHS K08 AR068409NIAMS NIH HHS R01 AR055309NIAMS NIH HHS R21 AR066821NIDDK NIH HHS P30 DK063720
Abstract
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of T
Indexed as
AnimalsEpithelial CellsHair FollicleHumansInflammationJagged-1 ProteinMiceStem CellsT-Lymphocytes, RegulatoryJagged-1 Proteinalopecia areatahairhair follicle stem cellhair regenerationJagged 1Notchregulatory T cellskin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.