ArticlePharmaceutical biology2017
In vitro evaluation of Spirulina platensis extract incorporated skin cream with its wound healing and antioxidant activities.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Effect ofNutrients · 2021Pooled it
- Microalgae as a Novel Therapy for Chronic Wound Healing.International wound journal · 2026Review
- Neuroprotective and Antioxidant Study ofCurrent aging science · 2026Article
- Microalgae: emerging forces and prospects in the field of wound healing.Burns & trauma · 2026Review
- TLC-bioautography-guided valorization of vetiver (Chrysopogon spp.) leaf extracts into an anti-acne gel.Bioresources and bioprocessing · 2025Article
- Microalgae: revolutionizing skin repair and enhancement.Biotechnology reports (Amsterdam, Netherlands) · 2025Review
- Spirulina as a Key Ingredient in the Evolution of Eco-Friendly Cosmetics.Biotech (Basel (Switzerland)) · 2025Review
- Hepatoprotective, anti-inflammatory, and wound healing effects of spirulina in rats.Journal of advanced veterinary and animal research · 2025Article
- Therapeutic potential of microalgae-derived natural compounds in diabetic wound healing: A comprehensive review.Heliyon · 2025Review
- Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit.Heliyon · 2024Article
- Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.Medicina (Kaunas, Lithuania) · 2023Review
- Microalgae's polysaccharides, are they potent antioxidants? Critical review.Archives of microbiology · 2023Review
- Chitosan Sponges for Efficient Accumulation and Controlled Release of C-Phycocyanin.Biotech (Basel (Switzerland)) · 2023Article
- Oral Palatability and Owners' Perception of the Effect of Increasing Amounts of Spirulina (Animals : an open access journal from MDPI · 2023Article
- Enhanced Wound Healing Potential ofMarine drugs · 2023Article
- Effects ofPlants (Basel, Switzerland) · 2023Article
- The antioxidant, wound healing properties and proteomic analysis of water extracts from the tropical cyanobacteria, Nostoc NIES-2111_MUM004.3 Biotech · 2023Article
- NovelPharmaceuticals (Basel, Switzerland) · 2022Article
- The Potential ofNutrients · 2022Review
- Advances in delivery methods ofBioengineered · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAlgae have gained importance in cosmeceutical product development due to their beneficial effects on skin health and therapeutical value with bioactive compounds. Spirulina platensis Parachas (Phormidiaceae) is renowned as a potential source of high-value chemicals and recently used in skincare products.
objectiveThis study develops and evaluates skin creams incorporated with bioactive S. platensis extract. MATERIALS AND
methodsSpirulina platensis was cultivated, the aqueous crude extract was prepared and in vitro cytotoxicity of S. platensis extract in the range of 0.001-1% concentrations for 1, 3 and 7 d on HS2 keratinocyte cells was determined. Crude extracts were incorporated in skin cream formulation at 0.01% (w/w) concentration and in vitro wound healing and genotoxicity studies were performed. Immunohistochemical staining was performed to determine the collagen activity.
results0.1% S. platensis extract exhibited higher proliferation activity compared with the control group with 198% of cell viability after 3 d. Skin cream including 1.125% S. platensis crude extract showed enhanced wound healing effect on HS2 keratinocyte cell line and the highest HS2 cell viability % was obtained with this concentration. The micronucleus (MN) assay results indicated that S. platensis extract incorporated creams had no genotoxic effect on human peripheral blood cells. Immunohistochemical analysis showed that collagen 1 immunoreactivity was improved by increased extract concentration and it was strongly positive in cells treated with 1.125% extract incorporated skin cream.
conclusionsThe cell viability, wound healing activity and genotoxicity results showed that S. platensis incorporated skin cream could be of potential value in cosmeceutical and biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.