Evidence map›Paper›PMID 28551870›Full record

ReviewJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2017

Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Baldomero M Olivera, Shrinivasan Raghuraman, Eric W Schmidt, Helena Safavi-Hemami

Abstract readReview
In one paragraph

Review in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Malacologia · 2025
    Article
  4. Prey Shifts Drive Venom Evolution in Cone Snails.Molecular biology and evolution · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Baldomero M OliveraDepartment of Biology, University of Utah, Salt Lake City, UT, 84112, USA.ORCID http://orcid.org/0000-0003-4556-1410
Shrinivasan RaghuramanDepartment of Biology, University of Utah, Salt Lake City, UT, 84112, USA.
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
Helena Safavi-HemamiDepartment of Biology, University of Utah, Salt Lake City, UT, 84112, USA. helena.safavi@utah.edu.

Funding

Venoms, Biological Resources, Molecular BiologyP01GM048677 · NIGMS · UNIVERSITY OF UTAH · PI BANDYOPADHYAY, PRADIP K · 1993 to 2018
$32.2M
Diverse drug lead compounds from bacterial symbionts in tropical marine mollusksU01TW008163 · FIC · OREGON HEALTH & SCIENCE UNIVERSITY · PI HAYGOOD, MARGO GENEVIEVE · 2008 to 2013
$4.3M
FIC NIH HHS U01 TW008163NIGMS NIH HHS P01 GM048677
6 · The paper itself

Abstract

From a biological perspective, a natural product can be defined as a compound evolved by an organism for chemical interactions with another organism including prey, predator, competitor, pathogen, symbiont or host. Natural products hold tremendous potential as drug leads and have been extensively studied by chemists and biochemists in the pharmaceutical industry. However, the biological purpose for which a natural product evolved is rarely addressed. By focusing on a well-studied group of natural products-venom components from predatory marine cone snails-this review provides a rationale for why a better understanding of the evolution, biology and biochemistry of natural products will facilitate both neuroscience and the potential for drug leads. The larger goal is to establish a new sub-discipline in the broader field of neuroethology that we refer to as "Chemical Neuroethology", linking the substantial work carried out by chemists on natural products with accelerating advances in neuroethology.

Indexed as

Biological EvolutionAnimalsBiological ProductsConus SnailFishesPredatory BehaviorBiological ProductsChemical neuroethologyCone snail venomNatural productsToxin cabals

Identifiers

PMID28551870
PMCPMC5656512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.