Evidence map›Paper›PMID 28551816›Full record

ReviewCurrent genetics2017

3D clustering of co-regulated genes and its effect on gene expression.

Manyu Du, Lu Bai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Transcription Factor Condensates Mediate Clustering ofbioRxiv : the preprint server for biology · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Condensin action and compaction.Current genetics · 2019
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Manyu DuDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, State College, PA, USA.
Lu BaiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, State College, PA, USA. lub15@psu.edu.ORCID http://orcid.org/0000-0003-3667-2944
Pennsylvania State University · US

Funding

Gene Regulation from Long-Distance Chromosomal Interactions in YeastR01GM118682 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BAI, LU · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM118682
6 · The paper itself

Abstract

There are extensive long-distance chromosomal interactions in eukaryotic genomes, but to what extent these interactions affect gene expression is not clear. Recent works have identified several cases where clustering of co-regulated genes leads to enhanced gene expression in budding yeast. Similar phenomenon was also observed in mammalian cells. These results challenge widely held views of gene regulation in yeast and further our understanding of how the 3D organization of the genome contribute to gene regulation in eukaryotes.

Indexed as

Gene Expression Regulation, FungalMultigene FamilyTranscription, GeneticAnimalsBasic-Leucine Zipper Transcription FactorsChromosomes, FungalEukaryotic CellsGalactokinaseGalactoseHumansIsoenzymesNF-kappa BProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBasic-Leucine Zipper Transcription FactorsGAL1 protein, S cerevisiaeGalactokinaseGalactoseIsoenzymesMET4 protein, S cerevisiaeNF-kappa BSaccharomyces cerevisiae Proteins3D clusteringChromosome configuration captureLong-distance chromosomal interactionLong-distance gene regulation

Identifiers

PMID28551816
PMCPMC5884626
OpenAlexW2617056721

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.