Evidence map›Paper›PMID 28551767›Full record

ArticleJournal of cancer research and clinical oncology2017

Does rarity mean imparity? Biological characteristics of osteosarcoma cells originating from the spine.

Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Cheng Yang, Haifeng Wei, Xinghai Yang, Jianru Xiao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhenhua ZhouDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.
Yan LiDepartment of Oncology, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.
Xu YanDepartment of Orthopaedics, The 455th Hospital of PLA, Shanghai, China.
Xudong WangDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.
Cheng YangDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.
Haifeng WeiDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.
Xinghai YangDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.
Jianru XiaoDepartment of Orthopaedic Oncology, Changzheng Hospital, The Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China. jianruxiao63@126.com.ORCID http://orcid.org/0000-0001-7498-9235
Second Military Medical University · CNChinese People 's Liberation Army No.455 Hospital · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOsteosarcoma is one of the most common malignancies in bones and is often found in limbs. Until now, it is not clear why osteosarcoma is rare in the spine. On the other hand, previous biological characteristics study about osteosarcoma of spine was also rare because of its low incidence. To explore the biology of spinal osteosarcoma, a stable osteosarcoma cell line derived from spine is necessary.

methodsA novel osteosarcoma cell line named NEO217 was established from spinal osteosarcoma tissues obtained from a Chinese male patient. We performed a series of experiments to investigate the biological properties of NEO217, including cell morphology, the kinetics of cell growth, biomarkers and tumorigenicity.

resultsThe cell line NEO217 was passaged in vitro for more than 50 generations. Ultramicroscopic structural features of these cells were consistent with the pleomorphism characteristic of cancer cells. The average cell doubling time was 26 h. The chromosomal morphology was that of a human karyotype, with the number of chromosomes more than 80. NEO217 cells and available osteosarcoma cell lines such as MG-63 and MNNG/HOS were all CD29

conclusionWe have established a novel osteosarcoma cell line NEO217 derived from the spine, which will provide a useful model for biological or therapeutical studies of spinal osteosarcoma.

Indexed as

Cell Line, TumorAnimalsCell Growth ProcessesGene ExpressionHumansKaryotypingMaleMiceMice, Inbred BALB CMice, NudeNeoplasm StagingOsteosarcomaSpinal NeoplasmsBiomarkerCell lineOsteosarcomaSpineTumor biology

Identifiers

PMID28551767
PMCPMC11819062
OpenAlexW2619749272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.