Evidence map›Paper›PMID 28551729›Full record

SynthesisClinical oral investigations2017

Use of platelet-rich fibrin in regenerative dentistry: a systematic review.

Richard J Miron, Giovanni Zucchelli, Michael A Pikos, Maurice Salama, Samuel Lee, Vincent Guillemette, Masako Fujioka-Kobayashi, Mark Bishara, Yufeng Zhang, Hom-Lay Wang and 9 more

7 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 273 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
273citing papers in PubMed, 23 pooled it
35.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03734458 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Platelet Rich Fibrin and Autologous Fibrin Glue for Treating Periodontal Recession Defects: a Comparative Clinical Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2021Enrolled0ConditionsGingival RecessionArmsGroup A - PRF plus AFG with a CAF, Group B - PRF only with a CAF, Group C - CTG with a CAF
NCT03985033 nacompletednot on this mapstarted 2019, after this paper: background citation

The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing: a Randomized Controlled Trial

TypeinterventionalSponsorThe European Research Group on Periodontology (ERGOPerio)Ran2019 to 2021Enrolled18ConditionsTooth ExtractionArmsleucocyte and platelet-rich fibrin (L-PRF)
NCT03992638 nacompletednot on this mapstarted 2019, after this paper: background citation

Mechanisms of LPRF Action in the Promotion of Wound Healing and Tissue Regeneration: A Randomised Controlled Trial

TypeinterventionalSponsorThe European Research Group on Periodontology (ERGOPerio)Ran2019 to 2022Enrolled12ConditionsGingival RecessionArmsleucocyte and platelet-rich fibrin (L-PRF) in combination with CAF, CAF
NCT04248049 nacompletednot on this mapstarted 2018, after this paper: background citation

Clinical Evaluation of Coronal Advanced Flap and Platelet Rich Fibrin on Root Coverage of Gingival Recessions Over a Period of 24 Month.

TypeinterventionalSponsorUniversidad Antonio NariñoRan2018 to 2019Enrolled15ConditionsGingival RecessionArmsPlatelet rich fibrin
NCT06679283 narecruitingnot on this mapstarted 2025, after this paper: background citation

Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) Compared With Open Flap Debridement (OFD) Alone: A 12-month Randomised Clinical Trial

TypeinterventionalSponsorUniversity of BernRan2025 to 2027Enrolled40ConditionsPeri-Implantitis, Bone Resorption, Platelet-Rich FibrinArmsOpen flap debridement with a chemo-electric device + PRF, Open flap debridement with a chemo-electric device alone (control)
NCT06814418 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

The Effect of Injectable Platelet Rich Fibrin (iPRF) in Non-surgical Periodontal Treatment- A Randomized Controlled Clinical Trial

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2023 to 2025Enrolled32ConditionsPeriodontitisArmsNon-surgical periodontal treatment, Injectable Platelet Rich Fibrin (I-PRF)
NCT07387913 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Evaluation of the Effect of Leucocyte Platelet-Rich Fibrin (L-PRF) Technique Applied in Post-extraction Sockets Before Placement of Dental Implants

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2022 to 2026Enrolled40ConditionsL-PRF, Dental Implants, Osseointegration, Alveolar Bone GraftingArmsAllograft and collagen membrane, Allograft and L-PRF membrane, L-PRF
3 · Its place in the literature

Who cites it

273 citing papers in PubMed, 23 syntheses or guidelines pooled it, 502 citations in OpenAlex.

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213 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 9 countries.

Richard J MironCollege of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA. richard.miron@zmk.unibe.ch.
Giovanni ZucchelliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Michael A PikosPikos Institute, Tampa Bay, FL, USA.
Maurice SalamaCollege of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA.
Samuel LeeInternational Academy of Dental Implantology, San Diego, CA, USA.
Vincent GuillemetteDepartment of Periodontology, Laval University, Quebec City, Canada.
Masako Fujioka-KobayashiCollege of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA.
Mark BisharaWest Bowmanville Dental, Bowmanville, Ontario, Canada.
Yufeng ZhangDepartment of Oral Implantology, University of Wuhan, Wuhan, China.
Hom-Lay WangDepartment of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA.
Fatiha ChandadDepartment of Periodontology, Laval University, Quebec City, Canada.
Cleopatra NacopoulosLaboratory for Research of the Musculoskeletal System, KAT Hospital, School of Medicine, National and Kapodistrian, University of Athens, Athens, Greece.
Alain SimonpieriOral Surgery Department, University Federico II Naples, Naples, Italy.
Alexandre Amir AalamDepartment of Advanced Periodontics, USC School of Dentistry, Los Angeles, CA, USA.
Pietro FeliceDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Gilberto SammartinoDepartment of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Shahram GhanaatiFORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Maria A HernandezCollege of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA.
Joseph ChoukrounPain Clinic, Nice, France.
Nova Southeastern University · USUniversité Laval · CAUniversity of Bologna · ITAmerican Academy of Implant Dentistry · USGoethe University Frankfurt · DEItalian Society of Periodontology and Implantology · ITNational and Kapodistrian University of Athens · GRSchool for Advanced Research · USUniversity of Bern · CHUniversity of Georgia · USUniversity of Michigan–Ann Arbor · USUniversity of Naples Federico II · ITWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesResearch across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation. MATERIALS AND

methodsManuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures. Only human randomized clinical trials were included for assessment.

resultsIn total, 35 articles were selected and divided accordingly (kappa = 0.94). Overall, the use of PRF has been most investigated in periodontology for the treatment of periodontal intrabony defects and gingival recessions where the majority of studies have demonstrated favorable results in soft tissue management and repair. Little to no randomized clinical trials were found for extraction socket management although PRF has been shown to significantly decrease by tenfold dry sockets of third molars. Very little to no data was available directly investigating the effects of PRF on new bone formation in GBR, horizontal/vertical bone augmentation procedures, treatment of peri-implantitis, and sinus lifting procedures.

conclusionsMuch investigation now supports the use of PRF for periodontal and soft tissue repair. Despite this, there remains a lack of well-conducted studies demonstrating convincingly the role of PRF during hard tissue bone regeneration. Future human randomized clinical studies evaluating the use of PRF on bone formation thus remain necessary. CLINICAL RELEVANCE: PRF was shown to improve soft tissue generation and limit dimensional changes post-extraction, with little available data to date supporting its use in GBR.

Indexed as

Bone RegenerationGuided Tissue Regeneration, PeriodontalPlatelet-Rich FibrinHumansBone augmentationPlatelet-rich fibrinSoft tissue regenerationTissue regeneration

Identifiers

PMID28551729
OpenAlexW2617852027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.