Evidence map›Paper›PMID 28551277›Full record

ReviewSeminars in fetal & neonatal medicine2017

An EXTrauterine environment for neonatal development: EXTENDING fetal physiology beyond the womb.

Emily A Partridge, Marcus G Davey, Matthew A Hornick, Alan W Flake

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Fetal echocardiographic assessment of cardiovascular impact of prolonged support on EXTrauterine Environment for Neonatal Development (EXTEND) system.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2020
    Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Emily A PartridgeDepartment of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Marcus G DaveyDepartment of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Matthew A HornickDepartment of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alan W FlakeDepartment of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: flake@email.chop.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extreme prematurity is a major cause of neonatal mortality and morbidity, and remains an unsolved clinical challenge. The development of an artificial womb, an extrauterine system recreating the intrauterine environment, would support ongoing growth and organ maturation of the extreme preterm fetus and would have the potential to substantially improve survival and reduce morbidity. Previous efforts toward the development of such a system have demonstrated the ability to maintain the isolated fetus for short periods of support, but have failed to achieve the long-term stability required for clinical application. Here we describe our initial experiments demonstrating the stable support of fetal lambs developmentally equivalent to the extreme premature infant for up to four weeks with stable hemodynamics, growth, and development. The achievement of long-term physiologic support of the fetus in an extrauterine system has the potential to fundamentally change the management and clinical outcome of the extreme premature infant.

Indexed as

Artificial OrgansPlacentaChild DevelopmentFemaleHumansInfant, NewbornInfant, PrematurePregnancyArtificial placentaExtracorporeal membrane oxygenationPreterm birthUmbilical cannulation

Identifiers

PMID28551277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.