Evidence map›Paper›PMID 28551033›Full record

ArticleJournal of autoimmunity2017

The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns.

Karen A Fortner, Jeffrey P Bond, James W Austin, Jeremy M Boss, Ralph C Budd

Abstract read
In one paragraph

Article in Journal of autoimmunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. A Framework for Understanding Maternal Immunity.Immunology and allergy clinics of North America · 2023
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. [Total glucosides of paeony inhibits proliferation and promotes activation- induced cell death of mouse T cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Autoimmunity in 2017.Clinical reviews in allergy & immunology · 2018
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karen A FortnerDepartment of Medicine, The University of Vermont College of Medicine, Burlington, VT 05405-0068, USA. Electronic address: Karen.fortner@uvm.edu.
Jeffrey P BondDepartment of Microbiology and Molecular Genetics, The University of Vermont College of Medicine, Burlington, VT 05405-0068, USA.
James W AustinDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Ralph C BuddDepartment of Medicine, The University of Vermont College of Medicine, Burlington, VT 05405-0068, USA.

Funding

Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2014 to 2026
$76.6M
Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4M
Vermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7M
Regulation of PD-1 gene expressionR01AI113021 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2014 to 2024
$4.7M
FAS REGULATES T CELL DEVELOPMENT/FUNCTION IN LPR MICER01AI036333 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI BUDD, RALPH C · 1996 to 2010
$3.7M
Upgrade of a FACS Aria Cell SorterS10OD018175 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2015 to 2015
$153k
NIAID NIH HHS R01 AI036333NIAID NIH HHS R01 AI113021NIAID NIH HHS U19 AI110483NIGMS NIH HHS P20 GM103449NIGMS NIH HHS P20 GM103496NIH HHS S10 OD018175
6 · The paper itself

Abstract

T lymphocyte homeostatic proliferation, driven by the engagement of T cell antigen receptor with self-peptide/major histocompatibility complexes, and signaling through the common γ-chain-containing cytokine receptors, is critical for the maintenance of the T cell compartment and is regulated by the Fas death receptor (Fas, CD95). In the absence of Fas, Fas-deficient lymphoproliferation spontaneous mutation (lpr) mice accumulate homeostatically expanded T cells. The functional consequences of sequential rounds of homeostatic expansion are not well defined. We thus examined the gene expression profiles of murine wild-type and Fas-deficient lpr CD8

Indexed as

AnimalsBiomarkersCell ProliferationCell SurvivalComputational BiologyCytotoxicity, ImmunologicDisease Models, AnimalFemaleGene Expression ProfilingHomeostasisImmunomodulationInflammationLymphocyte ActivationMiceMice, TransgenicProgrammed Cell Death 1 ReceptorBiomarkersProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellCD8(+) T cellsCytolytic proteinsFas (CD95)Homeostatic proliferationInhibitory proteinsT lymphocytes

Identifiers

PMID28551033
PMCPMC5902411

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.