Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging.

Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Nirmala D Gopal, Tricia Naicker, Hendrik G Kruger, Thavendran Govender

Abstract read

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In one paragraph

Article in Journal of molecular histology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.6field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

Application of infrared matrix-assisted laser desorption electrospray ionization mass spectrometry for morphine imaging in brain tissue.Analytical and bioanalytical chemistry · 2023
Article
6-Monoacetylmorphine-antibody distribution in tissues from heroin-related death cases: An experimental study to investigate the distributive response.Journal of cellular and molecular medicine · 2022
Article
Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone.ACS omega · 2020
Article
Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging.Journal of molecular histology · 2019
Article
Balancing sufficiency and impact in reporting standards for mass spectrometry imaging experiments.GigaScience · 2018
Article
Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system.RSC advances · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Belin G TeklezgiCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

Annapurna PamreddyCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

Sooraj BaijnathCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

Nirmala D GopalDepartment of Criminology, University of KwaZulu-Natal, Durban, South Africa.

Tricia NaickerCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

Hendrik G KrugerCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa.

Thavendran GovenderCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, E-block, 6th floor, Room E1-06-016, Westville Campus, Durban, 4000, South Africa. govenderthav@ukzn.ac.za.ORCID http://orcid.org/0000-0003-2511-2503

University of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heroin is an illicit opioid drug which is commonly abused and leads to dependence and addiction. Heroin is considered a pro-drug and is rapidly converted to its major active metabolite 6-monoacetylmorphine (6-MAM) which mediates euphoria and reward through the stimulation of opioid receptors in the brain. The aim of this study was to investigate the distribution and localization of 6-MAM in the healthy Sprague Dawley rat brain following intraperitoneal (i.p) administration of heroin (10 mg/kg), using matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI), in combination with quantification via liquid chromatography mass spectrometry (LC-MS/MS). These findings revealed that 6-MAM is present both in plasma and brain tissue with a T

Indexed as

AnimalsBrainBrain ChemistryChromatography, LiquidHeroinMorphine DerivativesRatsRats, Sprague-DawleyReceptors, OpioidSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTandem Mass SpectrometryTime FactorsTissue Distribution6-O-monoacetylmorphineHeroinMorphine DerivativesReceptors, Opioid6-Monoacetylmorphine (6-MAM)BrainHeroinLiquid chromatography-tandem mass spectrometry (LC–MS/MS)Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)

Identifiers

PMID28550642

DOI10.1007/s10735-017-9726-3

OpenAlexW2617707226

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.