ArticleSocial psychiatry and psychiatric epidemiology2017
Drug abuse-associated mortality across the lifespan: a population-based longitudinal cohort and co-relative analysis.
Article in Social psychiatry and psychiatric epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Added Value of Pharmacotherapy to Cognitive Behavior Therapy And Vice Versa in the Treatment of Alcohol Use Disorders: A Systematic Review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Pooled it
- The changing landscape of substance use disorders over 30 years: insights on US state disparities and policy from the global burden of disease study.Population health metrics · 2026Article
- Explainable illicit drug abuse prediction using hematological differences.Scientific reports · 2025Article
- Article
- Physical activity in adult users of inpatient mental health services: A scoping review.PloS one · 2024Article
- Spatiotemporal patterns of drug use disorder in Sweden assessed using population-based registries.BMC public health · 2023Article
- A genetically informed Registered Report on adverse childhood experiences and mental health.Nature human behaviour · 2023Article
- Drug prescriptions preceding opioid-related deaths-a register study in forensic autopsy patients.PloS one · 2023Observational
- Does early drug use-related police contact predict premature mortality and morbidity: A population register-based study.Drug and alcohol review · 2022Article
- Measuring Substance-Related Disorders Using Canadian Administrative Health Databanks: Interprovincial Comparisons of Recorded Diagnostic Rates, Incidence Proportions and Mortality Rate Ratios.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- Alcohol Use Disorder and Risk of Suicide in a Swedish Population-Based Cohort.The American journal of psychiatry · 2020Article
- Familial transmission of externalizing syndromes in extended Swedish families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeNationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself.
methodDA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Registers. Mortality was obtained from the Swedish Mortality registry.
resultsWe examined all individuals born in Sweden 1955-1980 (n = 2,696,253), 75,061 of whom developed DA. The mortality hazard ratio (mHR) (95% CIs) for DA was 11.36 (95% CIs, 11.07-11.66), substantially higher in non-medical (18.15, 17.51-18.82) than medical causes (8.05, 7.77-8.35) and stronger in women (12.13, 11.52-12.77) than in men (11.14, 10.82-11.47). Comorbid smoking and alcohol use disorder explained only a small proportion of the excess DA-associated mortality. Co-relative analyses demonstrated substantial familial confounding in the DA-mortality association with the strongest direct effects seen in middle and late-middle ages. The mHR was highest for opiate abusers (24.57, 23.46-25.73), followed by sedatives (14.19, 13.11-15.36), cocaine/stimulants (12.01, 11.36-12.69), and cannabis (10.93, 9.94-12.03).
conclusionThe association between registry-ascertained DA and premature mortality is very strong and results from both non-medical and medical causes. This excess mortality arises both indirectly-from characteristics of drug-abusing persons-and directly from the effects of DA. Excess mortality of opiate abuse was substantially higher than that observed for all other drug classes. These results have implications for interventions seeking to reduce the large burden of DA-associated premature mortality.
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