Evidence map›Paper›PMID 28550497›Full record

ArticleVirchows Archiv : an international journal of pathology2017

Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes.

Yuki Fukumura, Yasuni Nakanuma, Yuko Kakuda, Masaru Takase, Takashi Yao

Abstract read
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Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuki FukumuraDepartment of Human Pathology, School of Medicine, Juntendo University, Hongo 2-1-1, Tokyo, 113-8421, Japan. yfuku@juntendo.ac.jp.ORCID http://orcid.org/0000-0002-7702-6634
Yasuni NakanumaDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
Yuko KakudaDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
Masaru TakaseDepartment of Clinical Laboratory, Koshigaya Municipal Hospital, Saitama, Japan.
Takashi YaoDepartment of Human Pathology, School of Medicine, Juntendo University, Hongo 2-1-1, Tokyo, 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraductal papillary epithelial neoplasms of the pancreatobiliary system (intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN)) seem to share many clinicopathological features; however, IPNB has not been fully characterized. In order to understand the clinicopathological/immunohistochemical features of IPNB better, we compared 52 cases of IPNB with 42 cases of IPMNs with mural nodules. The IPNB cases were divided into two groups according to their histological similarity and according to five key histological findings. All IPNB and IPMN cases mainly affected middle-aged to elderly people, predominantly men. Mucin hypersecretion was less frequent in IPNB compared to IPMN. Group 2 IPNB more frequently had a higher histopathological grade and more extensive stromal invasion than IPMN. Group 1 IPNB and IPMN were further classified into four subtypes (gastric, intestinal, pancreatobiliary, and oncocytic). Although each subtype of IPNB and IPMN showed similar histology, the immunohistochemical results were different. The gastric type of IPNB was less frequently positive for CDX2, and intestinal IPNB was more frequently positive for MUC1 and less frequently positive for MUC2, MUC5AC, and CDX2 compared to each subtype of IPMN, respectively. In conclusion, IPNB and IPMN have some clinicopathological features in common, but mucin hypersecretion was less frequent both in IPNBs than in IPMN. Group 2 IPNB differed from IPMN in several parameters of tumor aggressiveness. Additional clinicopathological and molecular studies should be performed with respect to the subtypes of IPNB and IPMN.

Indexed as

Adenocarcinoma, MucinousAdenocarcinoma, PapillaryAgedBile Duct NeoplasmsBiomarkers, TumorCarcinoma, Pancreatic DuctalFemaleHumansImmunohistochemistryMaleMiddle AgedPancreatic NeoplasmsBiomarkers, TumorIntraductal papillary neoplasmMucin secretionMucus core proteinPancreatobiliary system

Identifiers

PMID28550497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.