Evidence map›Paper›PMID 28550304›Full record

ArticleScientific reports2017

Identification of Na+/K+-ATPase inhibition-independent proarrhythmic ionic mechanisms of cardiac glycosides.

Cai Hong Koh, Jianjun Wu, Ying Ying Chung, Zhenfeng Liu, Rong-Rong Zhang, Ketpin Chong, Vladimir Korzh, Sherwin Ting, Steve Oh, Winston Shim and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Inhibition of BKCell death discovery · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Cai Hong KohNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Jianjun WuNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Ying Ying ChungNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Zhenfeng LiuNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Rong-Rong ZhangGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, P.R. China.
Ketpin ChongZebrafish Translational Unit, Institute of Molecular and Cell Biology, Singapore, 138673, Republic of Singapore.
Vladimir KorzhZebrafish Translational Unit, Institute of Molecular and Cell Biology, Singapore, 138673, Republic of Singapore.
Sherwin TingBioprocessing Technology Institute, A*STAR (Agency for Science, Technology and Research), Singapore, 138668, Singapore.
Steve OhBioprocessing Technology Institute, A*STAR (Agency for Science, Technology and Research), Singapore, 138668, Singapore.
Winston ShimNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore.
Hai-Yan TianGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, P.R. China. thytian@jnu.edu.cn.
Heming WeiNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, 169609, Republic of Singapore. wei.he.ming@nhcs.com.sg.
National Heart Centre Singapore · SGDuke-NUS Medical School · SGJinan University · CNAgency for Science, Technology and Research · SGBioprocessing Technology Institute · SGInstitute of Molecular and Cell Biology · SGInternational Institute of Molecular and Cell Biology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study explored the Na

Indexed as

AnimalsArrhythmias, CardiacBufanolidesCalciumCalcium Channels, L-TypeCardenolidesCardiac GlycosidesCell DifferentiationCell LineCHO CellsCricetulusEgtazic AcidERG1 Potassium ChannelHEK293 CellsHuman Embryonic Stem CellsHumans1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acidbufalinBufanolidesCACNA1C protein, humanCalciumCalcium Channels, L-TypecalotropinCardenolidesCardiac GlycosidescinobufaginEgtazic AcidERG1 Potassium ChannelKCNH2 protein, humanNAV1.5 Voltage-Gated Sodium ChannelOuabainSCN1B protein, humanSCN5A protein, humanVoltage-Gated Sodium Channel beta-1 Subunit

Identifiers

PMID28550304
PMCPMC5446409
OpenAlexW2755621730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.