Evidence map›Paper›PMID 28550260›Full record

ArticleJournal of Alzheimer's disease : JAD2017

Living Alone with Alzheimer's Disease: Data from SveDem, the Swedish Dementia Registry.

Pavla Cermakova, Maja Nelson, Juraj Secnik, Sara Garcia-Ptacek, Kristina Johnell, Johan Fastbom, Lena Kilander, Bengt Winblad, Maria Eriksdotter, Dorota Religa

Registry-linked trialAbstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05817188 (Translational Identification of Medication Repurposing Candidates to Slow Cognitive Decline in Dementia), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05817188 completednot on this mapstarted 2023, after this paper: background citation

Translational Identification of Medication Repurposing Candidates to Slow Cognitive Decline in Dementia

TypeobservationalSponsorKarolinska InstitutetRan2023 to 2025Enrolled100,000ConditionsAlzheimer Dementia, Dementia DisordersArmsNo intervention
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
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  12. Association of Family Support With Lower Modifiable Risk Factors for Dementia Among Cognitively Impaired Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
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  13. Hospital admissions and emergency department visits for people with dementia.QJM : monthly journal of the Association of Physicians · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pavla CermakovaDepartment of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Maja NelsonDepartment of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Juraj SecnikDepartment of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Sara Garcia-PtacekDepartment of Neurobiology, Care Sciences andSociety, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.
Kristina JohnellAging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Johan FastbomAging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Lena KilanderDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Bengt WinbladDepartment of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Maria EriksdotterDepartment of Neurobiology, Care Sciences andSociety, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.
Dorota ReligaDepartment of Neurobiology, Care Sciences andSociety, Division of Neurogeriatrics, Karolinska Institutet, Huddinge, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany people with Alzheimer's disease (AD) live alone in their own homes. There is a lack of knowledge about whether these individuals receive the same quality of diagnostics and treatment for AD as patients who are cohabiting.

objectivesTo investigate the diagnostic work-up and treatment of community-dwelling AD patients who live alone.

methodsWe performed a cross-sectional cohort study based on data from the Swedish Dementia Registry (SveDem). We studied patients diagnosed with AD between 2007 and 2015 (n = 26,163). Information about drugs and comorbidities was acquired from the Swedish Prescribed Drug Register and the Swedish Patient Register.

results11,878 (46%) patients lived alone, primarily older women. After adjusting for confounders, living alone was inversely associated with receiving computed tomography (OR 0.90; 95% CI 0.82-0.99), magnetic resonance imaging (OR 0.91; 95% CI 0.83-0.99), and lumbar puncture (OR 0.86; 95% CI 0.80-0.92). Living alone was also negatively associated with the use of cholinesterase inhibitors (OR 0.81; 95% CI 0.76; 0.87), memantine (OR 0.77; 95% CI 0.72; 0.83), and cardiovascular medication (OR 0.92; 0.86; 0.99). On the other hand, living alone was positively associated with the use of antidepressants (OR 1.15; 95% CI 1.08; 1.22), antipsychotics (OR 1.41; 95% CI 1.25; 1.58), and hypnotics and sedatives (OR 1.09; 95% CI 1.02; 1.17).

conclusionsSolitary living AD patients do not receive the same extent of care as those who are cohabiting.

Indexed as

RegistriesSocial ConditionsAgedAged, 80 and overAlzheimer DiseaseAntidepressive AgentsAntipsychotic AgentsCohort StudiesComorbidityDementiaFemaleHumansIndependent LivingMagnetic Resonance ImagingMaleSwedenAntidepressive AgentsAntipsychotic AgentsAlzheimer’s diseasedementiadiagnosticssolitary livingtreatment

Identifiers

PMID28550260
PMCPMC5523910

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.