Evidence map›Paper›PMID 28550199›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.

Michael Schmueck-Henneresse, Bilal Omer, Thomas Shum, Haruko Tashiro, Maksim Mamonkin, Natalia Lapteva, Sandhya Sharma, Lisa Rollins, Gianpietro Dotti, Petra Reinke and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 52 citations in OpenAlex.

  1. ReducingCancer immunology research · 2018
    Trial
  2. Article
  3. Article
  4. Effects of CRISPR-Cas9-mediatedMolecular therapy. Methods & clinical development · 2025
    Article
  5. CAR-T cell therapy for cancer: current challenges and future directions.Signal transduction and targeted therapy · 2025
    Review
  6. Memory matters: T cell phenotype shapes CAR T cell fate.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Light-inducible T cell engagers trigger, tune, and shape the activation of primary T cells.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Michael Schmueck-HenneresseInstitute for Medical Immunology, Charité University Medicine Berlin, D-13353 Berlin, Germany; michael.schmueck-henneresse@charite.de.
Bilal OmerCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1479-5305
Thomas ShumCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Haruko TashiroCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-9038-1710
Maksim MamonkinCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Natalia LaptevaCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Sandhya SharmaCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-9183-1894
Lisa RollinsCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Gianpietro DottiCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.
Petra ReinkeRenal and Transplant Research Unit, Department of Nephrology and Internal Intensive Care, Charité University Medicine Berlin, D-13353 Berlin, Germany.
Hans-Dieter VolkInstitute for Medical Immunology, Charité University Medicine Berlin, D-13353 Berlin, Germany.
Cliona M RooneyCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-3210-2864
Baylor College of Medicine · USBerlin-Brandenburger Centrum für Regenerative Therapien · DE

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4M
VECTOR PRODUCTIONP01CA094237 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HESLOP, HELEN E, ROONEY, CLIONA M. · 2002 to 2017
$27.8M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAMK12CA090433 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CARL E ALLEN, Donald W. Parsons · 2002 to 2026
$18.5M
Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Training In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS K12 CA090433NCI NIH HHS P01 CA094237NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752NCRR NIH HHS S10 RR024574NHLBI NIH HHS T32 HL092332NIAID NIH HHS P30 AI036211NIDDK NIH HHS T32 DK060445
6 · The paper itself

Abstract

The outcome of therapy with chimeric Ag receptor (CAR)-modified T cells is strongly influenced by the subset origin of the infused T cells. However, because polyclonally activated T cells acquire a largely CD45RO

Indexed as

CD28 AntigensCD3 ComplexCell DifferentiationCytotoxicity, ImmunologicFlow CytometryHumansImmunophenotypingInterleukin-15Interleukin-2Interleukin-7Leukocyte Common AntigensLymphocyte ActivationReceptors, Antigen, T-CellT-Lymphocyte SubsetsCD28 AntigensCD3 ComplexInterleukin-15Interleukin-2Interleukin-7Leukocyte Common AntigensReceptors, Antigen, T-Cell

Identifiers

PMID28550199
PMCPMC5536854
OpenAlexW2618359715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.