Evidence map›Paper›PMID 28550190›Full record

ArticleHaematologica2017

Patient-derived anti-β2GP1 antibodies recognize a peptide motif pattern and not a specific sequence of residues.

Philippe de Moerloose, Céline Fickentscher, Françoise Boehlen, Jean-Marie Tiercy, Egbert K O Kruithof, Karim J Brandt

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Philippe de MoerlooseDivision of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Switzerland.
Céline FickentscherDivision of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Switzerland.
Françoise BoehlenDivision of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Switzerland.
Jean-Marie TiercyNational Reference Laboratory for Histocompatibility, Transplantation Immunology Unit, Department of Genetic and Laboratory Medicine, University Hospital of Geneva and Faculty of Medicine, Switzerland.
Egbert K O KruithofDivision of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Switzerland.
Karim J BrandtDivision of Angiology and Hemostasis, University Hospital of Geneva and Faculty of Medicine, Switzerland karim.brandt@hcuge.ch.
University Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid antibody syndrome is an autoimmune disease characterized by the presence of so-called antiphospholipid antibodies and clinical manifestations such as recurrent thromboembolic or pregnancy complications. Although the main antigenic determinant for antiphospholipid antibodies has been identified as the β-2-glycoprotein 1 (β2GP1), the precise epitope recognized by antiphospholipid antibodies still remains largely unknown. In the study herein, we wanted to identify a sequence in domain I of β2GP1 able to induce the proliferation of CD4

Indexed as

Amino Acid MotifsAmino Acid SequenceAntibodies, AntiphospholipidAutoantibodiesbeta 2-Glycoprotein ICD4-Positive T-LymphocytesCell ProliferationEpitopesHumansAntibodies, AntiphospholipidAutoantibodiesbeta 2-Glycoprotein IEpitopes

Identifiers

PMID28550190
PMCPMC5541867
OpenAlexW2618823359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.