Evidence map›Paper›PMID 28550188›Full record

ArticleHaematologica2017

Recommendations regarding splenectomy in hereditary hemolytic anemias.

Achille Iolascon, Immacolata Andolfo, Wilma Barcellini, Francesco Corcione, Loïc Garçon, Lucia De Franceschi, Claudio Pignata, Giovanna Graziadei, Dagmar Pospisilova, David C Rees and 13 more

Abstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Splenectomy for people with thalassaemia major or intermedia.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Cryohydrocytosis: When Cold Breaks the Membrane.American journal of hematology · 2026
    Article
  7. Article
  8. Moyamoya syndrome associated with hereditary spherocytosis: pathogenesis, management, and an illustrative case with rapid radiological progression.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Molecular surprises in evaluations of red cell disorders.Hematology. American Society of Hematology. Education Program · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Achille IolasconDepartment of Molecular Medicine and Medical Biotechnology, University Federico II Naples, Italy achille.iolascon@unina.it.
Immacolata AndolfoDepartment of Molecular Medicine and Medical Biotechnology, University Federico II Naples, Italy.
Wilma BarcelliniOncohematology Unit, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy.
Francesco CorcioneDepartment of General Surgery, Monaldi Hospital A.O.R.N. dei Colli, Naples, Italy.
Loïc GarçonService d'Hématologie Biologique, CHU Amiens Picardie, Amiens, France.
Lucia De FranceschiDepartment of Medicine, University of Verona and AOUI-Verona, Italy.
Claudio PignataDepartment of Translational Medical Sciences, Federico II University of Naples, Italy.
Giovanna GraziadeiDepartment of Clinical Science and Community Health, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Italy.
Dagmar PospisilovaDepartment of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
David C ReesDepartment of Paediatric Haematology, King's College Hospital, King's College London School of Medicine, UK.
Mariane de MontalembertPediatrics Department, Necker Hospital, Paris, France.
Stefano RivellaDepartment of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, NY, USA; Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, PA, USA.
Antonella GambaleDepartment of Molecular Medicine and Medical Biotechnology, University Federico II Naples, Italy.
Roberta RussoDepartment of Molecular Medicine and Medical Biotechnology, University Federico II Naples, Italy.
Leticia RibeiroHematology Service, Hospital and University Center of Coimbra (CHUC), Portugal.
Jules Vives-CorronsRed Cell Pathology Unit, Hospital Clínic de Barcelona, Spain.
Patricia Aguilar MartinezLaboratory of Hematology, CHRU de Montpellier, Hôpital Saint Eloi, France.
Antonis KattamisFirst Department of Pediatrics, University of Athens, Greece.
Beatrice GulbisDepartment of Clinical Chemistry, Hôpital Erasme, U.L.B., Brussels, Belgium.
Maria Domenica CappelliniDepartment of Clinical Science and Community Health, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Italy.
Irene RobertsDepartment of Paediatrics, Children's Hospital, University of Oxford, John Radcliffe Hospital, UK.
Hannah TamaryPediatric Hematology Unit, Schneider Children's Medical Center of Israel, Petah Tiqva, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Working Study Group on Red Cells and Iron of the EHA

Funding

Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01 DK095112
6 · The paper itself

Abstract

Hereditary hemolytic anemias are a group of disorders with a variety of causes, including red cell membrane defects, red blood cell enzyme disorders, congenital dyserythropoietic anemias, thalassemia syndromes and hemoglobinopathies. As damaged red blood cells passing through the red pulp of the spleen are removed by splenic macrophages, splenectomy is one possible therapeutic approach to the management of severely affected patients. However, except for hereditary spherocytosis for which the effectiveness of splenectomy has been well documented, the efficacy of splenectomy in other anemias within this group has yet to be determined and there are concerns regarding short- and long-term infectious and thrombotic complications. In light of the priorities identified by the European Hematology Association Roadmap we generated specific recommendations for each disorder, except thalassemia syndromes for which there are other, recent guidelines. Our recommendations are intended to enable clinicians to achieve better informed decisions on disease management by splenectomy, on the type of splenectomy and the possible consequences. As no randomized clinical trials, case control or cohort studies regarding splenectomy in these disorders were found in the literature, recommendations for each disease were based on expert opinion and were subsequently critically revised and modified by the Splenectomy in Rare Anemias Study Group, which includes hematologists caring for both adults and children.

Indexed as

Anemia, Hemolytic, CongenitalGuidelines as TopicHumansSplenectomyThrombosis

Identifiers

PMID28550188
PMCPMC5541865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.