Evidence map›Paper›PMID 28550183›Full record

ArticleHaematologica2017

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma.

Aneta Mikulasova, Christopher P Wardell, Alexander Murison, Eileen M Boyle, Graham H Jackson, Jan Smetana, Zuzana Kufova, Ludek Pour, Viera Sandecka, Martina Almasi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 98 citations in OpenAlex.

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  5. Genomics Define Malignant Transformation in Myeloma Precursor Conditions.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Aneta MikulasovaMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Christopher P WardellMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Alexander MurisonCenter for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, London, UK.
Eileen M BoyleCenter for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, London, UK.
Graham H JacksonNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Jan SmetanaDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Zuzana KufovaFaculty of Medicine, University of Ostrava, Czech Republic.
Ludek PourDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno, Czech Republic.
Viera SandeckaDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno, Czech Republic.
Martina AlmasiDepartment of Clinical Hematology, University Hospital Brno, Czech Republic.
Pavla VsianskaDepartment of Clinical Hematology, University Hospital Brno, Czech Republic.
Evzen GregoraDepartment of Internal Medicine and Hematology, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Petr KuglikDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Roman HajekFaculty of Medicine, University of Ostrava, Czech Republic.
Faith E DaviesMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Gareth J MorganMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Brian A WalkerMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA bwalker2@uams.edu.
University Hospital Brno · CZUniversity of Arkansas for Medical Sciences · USInstitute of Cancer Research · GBMasaryk University · CZNewcastle University · GBUniversity Hospital Kralovske Vinohrady · CZUniversity Hospital Ostrava · CZUniversity of Ostrava · CZ

Funding

Tumor Cell-Microenvironment Interactions in the Molecular Pathogenesis of MultiplP01CA055819 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI BELLAMY, WILLIAM T · 1993 to 2013
$49.7M
Cancer Research UKNCI NIH HHS P01 CA055819
6 · The paper itself

Abstract

Monoclonal gammopathy of undetermined significance is a pre-malignant precursor of multiple myeloma with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as

Indexed as

Translocation, GeneticChromosomes, HumanFemaleFlow CytometryHumansMaleMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaNeoplasm ProteinsNeoplasm Proteins

Identifiers

PMID28550183
PMCPMC5685224
OpenAlexW2619843656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.