ArticleDisease models & mechanisms2017
Viral delivery of
Open access · goldAbstract read
In one paragraph
Article in Disease models & mechanisms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2022Pooled it
- Challenges of modelling TDP-43 pathology in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Review
- Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.Frontiers in molecular neuroscience · 2024Review
- Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges.Translational neurodegeneration · 2023Review
- C9orf72 poly-GA proteins impair neuromuscular transmission.Zoological research · 2023Article
- C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice.Frontiers in cellular neuroscience · 2023Article
- Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization.Brain communications · 2023Article
- Small junction, big problems: Neuromuscular junction pathology in mouse models of amyotrophic lateral sclerosis (ALS).Journal of anatomy · 2022Review
- Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects.Biomedicines · 2022Review
- Modelling amyotrophic lateral sclerosis in rodents.Nature reviews. Neuroscience · 2022Review
- Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives.Biomedicines · 2022Review
- Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease.Frontiers in molecular neuroscience · 2022Review
- Nearly 30 Years of Animal Models to Study Amyotrophic Lateral Sclerosis: A Historical Overview and Future Perspectives.International journal of molecular sciences · 2021Review
- Where and Why Modeling Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2021Review
- Inducible expression of humanDisease models & mechanisms · 2021Article
- An Integrated Approach to Studying Rare Neuromuscular Diseases Using Animal and Human Cell-Based Models.Frontiers in cell and developmental biology · 2021Review
- C9ORF72: What It Is, What It Does, and Why It Matters.Frontiers in cellular neuroscience · 2021Review
- Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion.Frontiers in cellular neuroscience · 2021Article
- ModelingFrontiers in cellular neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Saul Herranz-MartinDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Jayanth ChandranDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.ORCID 0000-0002-3486-8583
Katherine LewisDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Padraig MulcahyDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Adrian HigginbottomDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Callum WalkerDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Isabel Martinez-Pena Y ValenzuelaMolecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109-1048, USA.
Ross A JonesCentre for Integrative Physiology & Euan MacDonald Centre for Motor Neurone Disease Research, Hugh Robson Building, The University of Edinburgh, 15 George Square, Edinburgh EH8 9XD, UK.ORCID 0000-0002-1569-2500
Ian ColdicottDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.
Tommaso IannittiDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK.ORCID 0000-0002-4758-0562
Mohammed AkaabouneMolecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109-1048, USA.ORCID 0000-0003-1991-0963
Sherif F El-KhamisyDepartment of Molecular Biology and Biotechnology, Krebs and Sheffield Institute for Nucleic Acids, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0001-6781-3477
Thomas H GillingwaterCentre for Integrative Physiology & Euan MacDonald Centre for Motor Neurone Disease Research, Hugh Robson Building, The University of Edinburgh, 15 George Square, Edinburgh EH8 9XD, UK.ORCID 0000-0002-0306-5577
Pamela J ShawDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK pamela.shaw@sheffield.ac.uk m.azzouz@sheffield.ac.uk.
Mimoun AzzouzDepartment of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), The University of Sheffield, 385A Glossop Road, Sheffield S10 2HQ, UK pamela.shaw@sheffield.ac.uk m.azzouz@sheffield.ac.uk.ORCID 0000-0001-6564-5967
University of Sheffield · GBUniversity of Edinburgh · GBUniversity of Michigan · US
Funding
European Research Council 294745Medical Research Council G1001492Medical Research Council MR/M010864/1Wellcome Trust
Abstract
Intronic GGGGCC repeat expansions in
Indexed as
Behavior, AnimalGene Transfer TechniquesAnimalsBiomarkersBrainC9orf72 ProteinCA1 Region, HippocampalCell DeathCell NucleusCognitionDependovirusDNA Repeat ExpansionGaitHEK293 CellsHumansMiceBiomarkersC9orf72 ProteinRNASequestosome-1 ProteinSqstm1 protein, mouseALS/FTDC9orf72C9RAN aggregatesMouse modelNeurodegeneration
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.