ArticleMolecular and cellular endocrinology2017
Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling.
Article in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Differential responsiveness and signaling pathways for prostaglandin F2a on chemokine mRNA in bovine corpus luteum and luteinized granulosa cells.Domestic animal endocrinology · 2025Article
- Luteal fibroblasts produce prostaglandins in response to IL1β in a MAPK-mediated manner.Molecular and cellular endocrinology · 2025Article
- Unraveling the role of lipid droplets and perilipin 2 in bovine luteal cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Basic fibroblast growth factor induces proliferation and collagen production by fibroblasts derived from the bovine corpus luteum†.Biology of reproduction · 2023Article
- Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum.Life science alliance · 2023Article
- Dynamics of inflammatory cytokine expression in bovine endometrial cells exposed to cow blood plasma small extracellular vesicles (sEV) may reflect high fertility.Scientific reports · 2023Article
- Mechanisms of angioregression of the corpus luteum.Frontiers in physiology · 2023Review
- A single-cell atlas of the cycling murine ovary.eLife · 2022Article
- Insights from two independent transcriptomic studies of the bovine corpus luteum during pregnancy.Journal of animal science · 2022Article
- History, insights, and future perspectives on studies into luteal function in cattle.Journal of animal science · 2022Review
- Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro.BMC genomics · 2021Article
- Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo.Biological research · 2021Article
- Protein Kinase A and 5' AMP-Activated Protein Kinase Signaling Pathways Exert Opposite Effects on Induction of Autophagy in Luteal Cells.Frontiers in cell and developmental biology · 2021Article
- Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function.Frontiers in endocrinology · 2019Review
- Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum.Data in brief · 2017Article
- Applications of large-scale molecular profiling techniques to the study of the corpus luteum.Animal reproductionArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α-provoked changes in the corpus luteum a short time-course (0.5-4 h) was performed on cows at midcycle. A microarray-determined transcriptome was established and examined by bioinformatic pathway analysis. Classic PGF2α effects were evident by changes in early response genes (FOS, JUN, ATF3) and prediction of active pathways (PKC, MAPK). Several cytokine transcripts were elevated and NF-κB and STAT activation were predicted by pathway analysis. Self-organizing map analysis grouped differentially expressed transcripts into ten mRNA expression patterns indicative of temporal signaling cascades. Comparison with two analogous datasets revealed a conserved group of 124 transcripts similarly altered by PGF2α treatment, which both, directly and indirectly, indicated cytokine activation. Elevated levels of cytokine transcripts after PGF2α and predicted activation of cytokine pathways implicate inflammatory reactions early in PGF2α-mediated luteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.