ArticleNeuroImage2017
Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia.Communications biology · 2025Article
- Mood variability during adolescent development and its relation to sleep and brain development.Scientific reports · 2024Article
- Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample.Network neuroscience (Cambridge, Mass.) · 2024Article
- Longitudinal Associations between Peer and Family Relationships, Emotional Symptoms, and Regional Brain Volume across Adolescence.Journal of youth and adolescence · 2023Article
- Comparing the stability and reproducibility of brain-behaviour relationships found using Canonical Correlation Analysis and Partial Least Squares within the ABCD Sample.bioRxiv : the preprint server for biology · 2023Article
- Cortico-amygdalar connectivity and externalizing/internalizing behavior in children with neurodevelopmental disorders.Brain structure & function · 2022Article
- Identifying profiles of brain structure and associations with current and future psychopathology in youth.Developmental cognitive neuroscience · 2021Article
- Structural Brain Development and Aggression: A Longitudinal Study in Late Childhood.Cognitive, affective & behavioral neuroscience · 2021Article
- Trajectories of depressive symptoms through adolescence as predictors of cortical thickness in the orbitofrontal cortex: An examination of sex differences.Psychiatry research. Neuroimaging · 2020Article
- Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study.NeuroImage · 2019Article
- Longitudinal structural brain development and externalizing behavior in adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Neural Markers of Resilience in Adolescent Females at Familial Risk for Major Depressive Disorder.JAMA psychiatry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAdolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural brain development. While much research has examined focal abnormalities in gray matter structure underlying depression, we employed a structural coupling approach to examine whether longitudinal associations between amygdala and cortical development (referred to as maturational coupling) was related to concurrent changes in depressive symptomatology during adolescence.
method166 participants underwent up to three MRI scans (367 scans) between 11 and 20 years of age. Depressive symptoms were measured at three coinciding time points using the Center for Epidemiological Studies-Depression scale. Linear mixed models were employed to identify whether change in amygdala volume was related to development of cortical thickness, and if maturational coupling of these regions was related to changes in depressive symptomatology.
resultsPositive maturational coupling was identified between the right amygdala and (predominantly anterior) prefrontal cortex, as well as parts of the temporal cortices. Greater positive coupling of these regions was associated with reductions in depressive symptoms over time.
conclusionsFindings highlight significant associations between cortico-amygdalar maturational coupling and the emergence of depressive symptoms during adolescence, suggesting that synchronous development of these regions might support more adaptive affect regulation and functioning.
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