Evidence map›Paper›PMID 28549735›Full record

ArticleBioorganic & medicinal chemistry letters2017

Optimization of the process of inverted peptides (PIPE

Quentin Seisel, Marisa Rädisch, Nicholas P Gill, Dean R Madden, Prisca Boisguerin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PPARStem cells international · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Quentin SeiselCentre de Recherche de Biologie cellulaire de Montpellier, CNRS UMR 5237, Université de Montpellier, 1919 Route de Mende, 34293 Montpellier Cedex 5, France.
Marisa RädischBioorganische Chemie, Universität Bayreuth, Gebäude NW I, 95440 Bayreuth, Germany.
Nicholas P GillDepartment of Biochemistry & Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755-3844, United States.
Dean R MaddenDepartment of Biochemistry & Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755-3844, United States.
Prisca BoisguerinCentre de Recherche de Biologie cellulaire de Montpellier, CNRS UMR 5237, Université de Montpellier, 1919 Route de Mende, 34293 Montpellier Cedex 5, France. Electronic address: prisca.boisguerin@crbm.cnrs.fr.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Molecular and Cellular Biology at DartmouthT32GM008704 · NIGMS · DARTMOUTH COLLEGE · PI COMPTON, DUANE A. · 1998 to 2018
$6.8M
Preclinical development of CFTR stabilizers targeting the CAL PDZ domainR01DK101541 · NIDDK · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2014 to 2017
$1.9M
NIDDK NIH HHS R01 DK101541NIGMS NIH HHS P20 GM113132NIGMS NIH HHS T32 GM008704
6 · The paper itself

Abstract

PDZ domains play crucial roles in cell signaling processes and are therefore attractive targets for the development of therapeutic inhibitors. In many cases, C-terminal peptides are the physiological binding partners of PDZ domains. To identify both native ligands and potential inhibitors we have screened arrays synthesized by the process of inverted peptides (PIPE), a variant of SPOT synthesis that generates peptides with free C-termini. Here, we present the development of a new functionalized cellulose membrane as solid support along with the optimized PIPE

Indexed as

Amino Acid SequenceChromatography, High Pressure LiquidLigandsPDZ DomainsPeptide LibraryPeptidesProtein BindingLigandsPeptide LibraryPeptidesCellulose functionalizationC-terminusPDZ domainPeptide arraySPOT synthesis

Identifiers

PMID28549735
PMCPMC5523833

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.