Evidence map›Paper›PMID 28549665›Full record

ArticleNitric oxide : biology and chemistry2017

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.

Hossam A Shaltout, Joel Eggebeen, Anthony P Marsh, Peter H Brubaker, Paul J Laurienti, Jonathan H Burdette, Swati Basu, Ashley Morgan, Patricia C Dos Santos, James L Norris and 8 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nitric oxide : biology and chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
11.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06131528 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Relaxation Breathing Exercises on Cardiovascular Parameters Among Hypertensive Patients

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled40ConditionsHypertensionArmsRelaxation Breathing Exercises Group, Usual Care Group
NCT06375694 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Oral Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production

TypeinterventionalSponsorWake Forest UniversityRan2024 to 2025Enrolled20ConditionsHypertension, Cardiovascular Diseases, DiabetesArmsHerbiotics Oral + Ent Probiotic, Placebo
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Trial
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  19. Article
  20. Ultra-Endurance Participation and Acute Kidney Injury: A Narrative Review.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Hossam A ShaltoutSection on Obstetrics & Gynecology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Joel EggebeenSections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Anthony P MarshDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA.
Peter H BrubakerDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA.
Paul J LaurientiTranslational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 2757, USA.
Jonathan H BurdetteTranslational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 2757, USA.
Swati BasuTranslational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Department of Physics, Wake Forest University, Winston-Salem, NC 27104, USA.
Ashley MorganDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 2757, USA.
Patricia C Dos SantosTranslational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Department of Chemistry, Wake Forest University, Winston-Salem, NC 27104, USA.
James L NorrisDepartment of Mathematics, Wake Forest University, Winston-Salem, NC 27104, USA.
Timothy M MorganDepartment of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Gary D MillerDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA.
W Jack RejeskiDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA.
Amret T HawfieldHypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Debra I DizHypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
J Thomas BectonSections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Daniel B Kim-ShapiroTranslational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA; Department of Physics, Wake Forest University, Winston-Salem, NC 27104, USA. Electronic address: shapiro@wfu.edu.
Dalane W KitzmanSections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27104, USA. Electronic address: dkitzman@wakehealth.edu.
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Effects of Nitric Oxide in Sickle Cell BloodR37HL058091 · NHLBI · WAKE FOREST UNIVERSITY · PI KIM-SHAPIRO, DANIEL B · 2007 to 2016
$3.5M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
Effects of Nitric Oxide in Sickle Cell BloodR01HL058091 · NHLBI · WAKE FOREST UNIVERSITY · PI KIM-SHAPIRO, DANIEL B · 2002 to 2006
$1.6M
SPRINT - HeartR01HL107257 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2011 to 2014
$1.5M
MECHANISM AND KINETICS OF SICKLE CELL HEMOGLOBINR29HL058091 · NHLBI · WAKE FOREST UNIVERSITY · PI KIM-SHAPIRO, DANIEL B · 1998 to 2002
$260k
NHLBI NIH HHS R01 HL058091NHLBI NIH HHS R01 HL107257NHLBI NIH HHS R29 HL058091NHLBI NIH HHS R37 HL058091NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R01 AG045551NIA NIH HHS R37 AG018915
6 · The paper itself

Abstract

Aerobic exercise training is an effective therapy to improve peak aerobic power (peak VO

Indexed as

Dietary SupplementsExerciseAgedBeta vulgarisBlood PressureFemaleFruit and Vegetable JuicesHeart FailureHumansHypertensionMiddle AgedNitratesNitritesOxygenPhysical EnduranceStroke VolumeNitratesNitritesOxygenExerciseHeart failure with preserved ejection fractionHypertensionNitrateNitric OxideNitrite

Identifiers

PMID28549665
PMCPMC5565697
OpenAlexW2619653059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.