ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017
Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 71 citations in OpenAlex.
- Different eGFR markers and prediction of cardiovascular risk.Journal of internal medicine · 2026Trial
- Effect of Dapagliflozin on Measured vs. Panel-Estimated Glomerular Filtration Rate.Clinical pharmacology and therapeutics · 2025Trial
- Impact of mGFR Versus eGFR on the Pharmacokinetics of a Renally Excreted Model Drug in Older Medical Patients: A Proof-of-Concept Trial.Kidney international reports · 2026Article
- A Comparative Study between Serum Cystatin C and Microalbuminuria in the Diagnosis of Nephropathy in Type 2 Diabetes Mellitus.Annals of African medicine · 2026Article
- Medications Influencing Serum Cystatin C Independent of Measured GFR.Journal of the American Society of Nephrology : JASN · 2026Article
- Sex Modifies the Association Between Planetary Health Diet Adherence and Kidney Function Decline in US Adults Aged 50 Years and Older.Nutrients · 2026Article
- Impact of Computed Tomography-Derived Body Composition Analysis on the Performance of GFR Estimating Equations in Patients with Cancer.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Comparison of Creatinine-, Cystatin C-, and Combined Creatinine-Cystatin C-Based Equations for Estimating Glomerular Filtration Rate: A Real-World Analysis in Patients with Chronic Kidney Disease.International journal of molecular sciences · 2025Article
- Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients.Scientific reports · 2025Article
- Unveiling mechanisms underlying kidney function changes during sex hormone therapy.The Journal of clinical investigation · 2025Observational
- Update on the Assessment of GFR in Patients with Cancer.Kidney360 · 2025Review
- Association between the difference in cystatin C and creatinine-based eGFR and risks of multiple cardiovascular diseases: a prospective cohort study.Frontiers in medicine · 2025Article
- Choice of Estimated GFR Concept and Implications for Cystatin C to Creatinine Ratio Among Hospitalized Older Adults.Kidney international reports · 2024Article
- Comparison of Glomerular Filtration Rate Equations in a Rural New Mexico Cohort: Results from the COMPASS Study.medRxiv : the preprint server for health sciences · 2024Article
- Drug stewardship in chronic kidney disease to achieve effective and safe medication use.Nature reviews. Nephrology · 2024Review
- Cystatin C- and Creatinine-based Estimated GFR Differences: Prevalence and Predictors in the UK Biobank.Kidney medicine · 2024Article
- Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis.Frontiers in medicine · 2024Review
- Incident Heart Failure Risk Reclassification With Race-Independent Estimated Glomerular Filtration Rate: A National Heart, Lung, and Blood Institute Pooled Cohorts Analysis.Journal of cardiac failure · 2024Article
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Cystatin C as a GFR Estimation Marker in Acute and Chronic Illness: A Systematic Review.Kidney medicine · 2023Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundStudies in chronic kidney disease populations suggest that the non-glomerular filtration rate (GFR) determinants of serum levels of the low-molecular-weight protein filtration markers cystatin C, β STUDY
designCross-sectional study. SETTING &
participantsPredominantly elderly participants selected from the Age, Gene/Environment Susceptibility Kidney Study (AGES-Kidney; N=683; mean [SD] age, 79 [4] years; GFR, 62 [17]mL/min/1.73 m PREDICTORS: Demographic and clinical factors hypothesized to be associated with conditions affecting non-GFR determinants of the filtration markers. OUTCOMES: Measured GFRs and estimated GFRs (eGFRs) based on creatinine, cystatin C, B2M, and BTP levels (eGFR
resultseGFR LIMITATIONS: Small sample size may limit power to detect associations. Participants may be healthier than the general population.
conclusionsSimilar to previous studies in chronic kidney disease, in community-dwelling elders, cystatin C, B2M, and BTP levels are less affected than creatinine level by age and sex and are not affected by ethnicity. Both cystatin C and B2M levels may be affected by inflammation. These findings are important for the development and use of GFR estimating equations based on low-molecular-weight serum proteins throughout the range in GFRs.
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Registered trials
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