Evidence map›Paper›PMID 28549535›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2017

Relationships of Measured Iohexol GFR and Estimated GFR With CKD-Related Biomarkers in Children and Adolescents.

Derek K Ng, George J Schwartz, Bradley A Warady, Susan L Furth, Alvaro Muñoz

Registry-linked trialAbstract read
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00327860 recruitingnot on this map

Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

TypeobservationalSponsorJohns Hopkins Bloomberg School of Public HealthRan2003 to 2028Enrolled1,300ConditionsChronic Kidney Disease
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Glomerular Filtration Rate Assessment in Children.Children (Basel, Switzerland) · 2022
    Review
  5. Review
  6. Renal function markers in single-kidney patients after percutaneous nephrolithotomy: A pilot study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022
    Article
  7. Review
  8. Review
  9. Observational
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Derek K NgDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: dng@jhu.edu.
George J SchwartzUniversity of Rochester Medical Center, Rochester, NY.
Bradley A WaradyChildren's Mercy Hospital, Kansas City, MO.
Susan L FurthThe Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Alvaro MuñozDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U01DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MUNOZ, ALVARO · 2003 to 2017
$17.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Central Biochemistry Laboratory of the CKiD ConsortiumU01DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2008 to 2017
$3.5M
NICHD NIH HHS U54 HD079123NIDDK NIH HHS U01 DK066116NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U01 DK082194
6 · The paper itself

Abstract

background2 valid and reliable estimated glomerular filtration rate (GFR) equations for the pediatric population have been developed from directly measured GFR data in the Chronic Kidney Disease in Children (CKiD) cohort: the full CKiD and bedside CKiD equations. Although adult GFR estimating equations replicate relationships of measured GFR with biomarkers, it is unclear whether similar patterns exist among children and adolescents with chronic kidney disease (CKD). STUDY

designProspective cohort study in children and adolescents. SETTINGS &

participants730 participants contributed 1,539 study visits. PREDICTORS: Measured GFR by plasma iohexol disappearance (mGFR), estimated GFR by the full CKiD equation (eGFR OUTCOMES & MEASUREMENTS: CKD-related biomarkers included values for urine protein-creatinine ratio, blood hemoglobin, serum phosphate, bicarbonate, potassium, systolic and diastolic blood pressure z scores, and height z scores.

resultsThe median age of 730 participants with CKD was 12.5 years, with median mGFR, eGFR LIMITATIONS: Simple linear summaries of biomarkers may not capture nonlinear associations.

conclusionseGFR

Indexed as

Renal Insufficiency, ChronicAdolescentBiomarkersBlood Urea NitrogenBody HeightChildCohort StudiesContrast MediaCreatinineCystatin CDisease ProgressionFemaleGlomerular Filtration RateHumansIohexolKidney Function TestsBiomarkersContrast MediaCreatinineCystatin CIohexoladolescentschildrenchronic kidney disease (CKD)Chronic Kidney Disease in Children (CKiD)CKD biomarkerestimated GFRGFR estimating equationglomerular filtration rate (GFR)iohexolkidney functionkidney measuremeasured GFRPediatric

Identifiers

PMID28549535
PMCPMC5572310

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.