ArticlePediatric rheumatology online journal2017
Early feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort.
Article in Pediatric rheumatology online journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2022Pooled it
- Early-life physical activity and risk of juvenile idiopathic arthritis: a longitudinal ABIS cohort study using a symptom-free baseline design.Pediatric rheumatology online journal · 2026Article
- Effects of a cow's milk protein-free diet as an adjunct to standard therapy in juvenile idiopathic arthritis: a randomized controlled study.BMC rheumatology · 2026Article
- Immunomodulatory Effects of Human Breast Milk-Derived Exosomes on Myeloid Cells and Chondrocytes.Biomolecules & therapeutics · 2026Article
- Comparative Analysis of Breastfeeding and Infant Formulas: Short- and Long-Term Impacts on Infant Nutrition and Health.Food science & nutrition · 2025Review
- One-year follow-up of a short specific carbohydrate diet intervention in children with juvenile idiopathic arthritis: A retrospectively controlled study with focus on medical burden.Clinical rheumatology · 2025Article
- Breastfeeding and Non-Communicable Diseases: A Narrative Review.Nutrients · 2025Review
- From Dysbiosis to Disease: The Microbiome's Influence on Uveitis Pathogenesis.Microorganisms · 2025Review
- Breastfeeding duration and the risk of systemic juvenile idiopathic arthritis: a cross-sectional study.Frontiers in nutrition · 2025Article
- Review
- Causal effect of gut microbiota on juvenile idiopathic arthritis: A two-sample Mendelian a randomization study.Journal of cellular and molecular medicine · 2024Article
- Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study.The Journal of rheumatology · 2024Article
- Breastfeeding decreases the risk of developing psoriasis through to early adulthood.The British journal of dermatology · 2024Article
- Article
- Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases.Environmental science & technology · 2024Article
- Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children.EBioMedicine · 2023Article
- The role of breastfeeding as a protective factor against the development of the immune-mediated diseases: A systematic review.Frontiers in pediatrics · 2023Review
- Whole exome sequencing in a juvenile idiopathic arthritis large family with SERPINA1 gene mutations.BMC rheumatology · 2022Article
- A Pilot Study Investigating Faecal Microbiota After Two Dietary Interventions in Children with Juvenile Idiopathic Arthritis.Current microbiology · 2022Article
- Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJuvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA.
methodsAll parents with children born between October 1, 1997 and October 1, 1999 in Southeast Sweden were asked to participate in the ABIS prospective cohort study (All Babies in Southeast Sweden), At 1 year, questionnaires with information on breastfeeding and introduction of foods were completed by 10,565 families. We identified 32 children with JIA and 111 children with non-chronic arthritis with completed questionnaires after delivery and after 1 year. A multivariable logistic regression model, adjusted for relevant factors, was performed to calculate the association between JIA and feeding during the first year of life.
resultsAn increased risk for JIA was found in children who had breast fed for less than 4 months, as opposed to those who were continued on breast milk beyond 4 months of age (aOR 3.5, 95% CI 1.4-8,5; p = 0.006). A short duration of exclusive as well as total breastfeeding was associated with an increased risk of JIA (aOR 1.3, 95% CI 1.1-1.6; p = 0.008 and aOR 1.2, 95% CI 1.1-1.3; p < 0.001). All associations between breastfeeding and JIA persisted after adjustment. There was no relationship between early nutrition and non-chronic arthritis.
conclusionsOur results indicate that there are different disease mechanisms for different types of arthritis in childhood. Longer duration of breastfeeding (both total and exclusive) may protect against development of JIA. Mothers should be encouraged to breast-feed their babies exclusively, if at all possible, for 4 months and continue partial breastfeeding for an extended time when foreign proteins are introduced.
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Registered trials
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