ArticleEndocrinology2017
Exposure to Acute Psychosocial Stress Disrupts the Luteinizing Hormone Surge Independent of Estrous Cycle Alterations in Female Mice.
Article in Endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
42 citing papers in PubMed, 64 citations in OpenAlex.
- Examining mechanisms by which acute psychosocial stress disrupts the proestrous LH surge and ovulation in female mice.Endocrinology · 2026Article
- Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility.Frontiers in neuroscience · 2026Review
- Restraint stress prolongs Diestrus phase of mouse Estrous cycle.Oxford open neuroscience · 2026Article
- Restraint Stress Prolongs Diestrus Phase of Mouse Estrous Cycle.bioRxiv : the preprint server for biology · 2025Article
- Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Sex and Time of Day Alter the Interactions Between Hypothalamic Glia and the Neural Circuits Controlling Reproduction.Endocrinology · 2025Article
- Suppression of Luteinizing Hormone Secretion in Female Mice by a Urocortin 2-CRHR2 Signaling Pathway.Endocrinology · 2025Article
- Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition.bioRxiv : the preprint server for biology · 2025Article
- Shifting GnRH Neuron Ensembles Underlie Successive Preovulatory Luteinizing Hormone Surges.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Article
- NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice.Journal of neuroendocrinology · 2024Article
- Effect of Bee Bread on Corticosterone Level in Rat Dams Exposed to Gestational Heat Stress.Tropical life sciences research · 2023Article
- Understanding the Diurnal Oscillation of the Gut Microbiota Using Microbial Culture.Life (Basel, Switzerland) · 2023Article
- Chemogenetic activation of PVN CRH neurons disrupts the estrous cycle and LH dynamics in female mice.Frontiers in endocrinology · 2023Article
- The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells.International journal of molecular sciences · 2022Article
- Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice.Physiological reports · 2022Article
- Elevated prolactin secretion during proestrus in mice: Absence of a defined surge.Journal of neuroendocrinology · 2022Article
- Regulation of the gonadotropin-releasing hormone neuron during stress.Journal of neuroendocrinology · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The disruptive effects of severe stress on reproductive function are well documented, but surprisingly few studies exist that demonstrate milder psychosocial stressors interfere with the ovarian cycle in females. We hypothesized repeated application of psychosocial stress would disrupt estrous cycles in mice. Mice were transferred to a new cage, transported to a new room, and restrained (2 hours) for 21 consecutive days. Contrary to our hypothesis, this paradigm did not affect estrous cycles. We next tested the hypothesis that a single exposure to mild stress disrupts a specific aspect of the cycle: the proestrous luteinizing hormone (LH) surge. We developed a model of acute, layered psychosocial stress (sequential application of new cage, transport to new room, restraint and predator cues lasting 5 hours total) that consistently increased circulating corticosterone. Application of this stress paradigm on midmorning of proestrus disrupted the LH surge measured near lights out in 14 of 24 mice; there was no evidence for a 24-hour delay of the surge. Following stress, mice continued to have normal estrous cycles, even when the LH surge was disrupted. Stressed mice failing to exhibit an LH surge had uterine masses suggesting the proestrous estradiol rise occurred. To test specifically whether the layered stress paradigm blocks estradiol-dependent positive feedback mechanisms, we examined the estradiol-induced LH surge. Stress blocked the estradiol-induced LH surge in all mice. These results suggest exposure to mild, acute psychosocial stress on proestrus can severely disrupt the generation of the LH surge in mice without affecting the overall estrous cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.