ArticleNMR in biomedicine2017
Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.
Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Gut Dysbiosis Serine-Glycine Metabolism and Glioblastoma: Exploring Therapeutic Opportunities.Cancers · 2026Review
- Simultaneous Detection of GABA and Glycine Using MEGA-PRESS With TE Optimization at 3T.Magnetic resonance in medicine · 2026Article
- Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas.NMR in biomedicine · 2025Article
- Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients.Journal of neuro-oncology · 2024Article
- Optimization of spectrally selective 180° radiofrequency pulse timings in J-difference editing (MEGA) of lactate.Magnetic resonance in medicine · 2022Article
- The potential ofPsychopharmacology · 2021Review
- Magnetic resonance spectroscopy for the study of cns malignancies.Progress in nuclear magnetic resonance spectroscopy · 2021Article
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.Neuro-oncology · 2020Article
- Elevated glycine detected on in vivo magnetic resonance spectroscopy in a breast cancer patient: case report and literature review.BJR case reports · 2020Article
- Metabolomic prostate cancer fields in HRMAS MRS-profiled histologically benign tissue vary with cancer status and distance from cancer.NMR in biomedicine · 2019Article
- Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3 T in vivo.Magnetic resonance in medicine · 2018Article
- Distinguishing Myo-Inositol From Glycine in Brain MRS at 3T: A Pitfall Using Intermediate Echo Times.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors. The precise measurement of Gly is challenging largely as a result of the spectral overlap with myo-inositol (mI). We report a new triple-refocusing sequence for the reliable co-detection of Gly and mI at 3 T and for the evaluation of Gly in healthy and tumorous brain. The sequence parameters were optimized with density-matrix simulations and phantom validation. With a total TE of 134 ms, the sequence gave complete suppression of the mI signal between 3.5 and 3.6 ppm and, consequently, well-defined Gly (3.55 ppm) and mI (3.64 ppm) peaks. In vivo
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.