SynthesisJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review.
Synthesis in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
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- Co-exposure to iron, copper, zinc, selenium and titanium is associated with the prevention of gastric precancerous lesions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Electrical Potentiometry with Intraoral Applications.Materials (Basel, Switzerland) · 2022Article
- Biocompatible Gas Plasma Treatment Affects Secretion Profiles but Not Osteogenic Differentiation in Patient-Derived Mesenchymal Stromal Cells.International journal of molecular sciences · 2022Article
- Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- The unfavorable role of titanium particles released from dental implants.Nanotheranostics · 2021Review
- The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Similitude of cement-bone micromechanics in cemented rat and human knee replacement.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Fourier transform infrared spectroscopic imaging of wear and corrosion products within joint capsule tissue from total hip replacements patients.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Effects of condensation and compressive strain on implant primary stability: A longitudinal, in vivo, multiscale study in mice.Bone & joint research · 2020Article
- Early Changes in Cement-Bone Fixation Using a Novel Rat Knee Replacement Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Inflammation and Bone Repair: From Particle Disease to Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We completed a systematic literature review of in vivo animal models that use arthrotomy-based methods to study particle-induced peri-implant osteolysis. The purpose of the review was to characterize the models developed to date, to determine the questions addressed, to assess scientific rigor and transparency, and to identify gaps in knowledge. We probed three literature databases (Medline, Embase, and Scopus) and found 77 manuscripts that fit the search parameters. In the most recent 10 years, researchers mainly used rat and mouse models, whereas in the previous 20 years, large animal, canine, and rabbit models were more common. The studies have demonstrated several pathophysiology pathways, including macrophage migration, particle phagocytosis, increased local production of cytokines and lysosomal enzymes, elevated bone resorption, and suppressed bone formation. The effect of variation in particle characteristics and concentration received limited attention with somewhat mixed findings. Particle contamination by endotoxin was shown to exacerbate peri-implant osteolysis. The possibility of early diagnosis was demonstrated through imaging and biomarker approaches. Several studies showed that both local and systemic delivery of bisphosphonates inhibits the development of particle-induced osteolysis. Other methods of inhibiting osteolysis include the use of anabolic agents and altering the implant design. Few studies examined non-surgical rescue of loosened implants, with conflicting results with alendronate. We found that the manuscripts often lacked the methodological detail now advocated by the ARRIVE guidelines, suggesting that improvement in reporting would be useful to maximize rigor and transparency. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2595-2605, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.