ArticleTissue engineering. Part C, Methods2017
The Yucatan Minipig Temporomandibular Joint Disc Structure-Function Relationships Support Its Suitability for Human Comparative Studies.
Article in Tissue engineering. Part C, Methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Bone Morphogenetic Protein-2 and Cabozantinib for Temporomandibular Joint Cartilage Repair: Murine and Porcine Injury Models.International journal of molecular sciences · 2026Article
- Scaffolds and Stem Cells Show Promise for TMJ Regeneration: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Characterization of the Age-Related Differences in Porcine Acetabulum and Femoral Head Articular Cartilage.Cartilage · 2025Article
- Impact of storage techniques on ovine temporomandibular joint discs composition and physicochemical properties.Frontiers in bioengineering and biotechnology · 2025Article
- Auricular Chondrocytes as a Cell Source for Scaffold-Free Elastic Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2024Article
- Role of periosteum during healing of alveolar critical size bone defects in the mandible: a pilot study.Clinical oral investigations · 2023Article
- Characterization of the Temporomandibular Joint Disc Complex in the Yucatan Minipig.Tissue engineering. Part A · 2023Article
- Navigating regulatory pathways for translation of biologic cartilage repair products.Science translational medicine · 2022Review
- Proteomic, mechanical, and biochemical development of tissue-engineered neocartilage.Biomaterials research · 2022Article
- The Effect of Neonatal, Juvenile, and Adult Donors on Rejuvenated Neocartilage Functional Properties.Tissue engineering. Part A · 2022Article
- Proteomic, mechanical, and biochemical characterization of cartilage development.Acta biomaterialia · 2022Article
- The functionality and translatability of neocartilage constructs are improved with the combination of fluid-induced shear stress and bioactive factors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Advances in Tissue Engineering of the Temporomandibular Joint Disc: An Overview of Current Status and Future Directions.International journal of dentistry · 2022Review
- Methodology to Quantify Collagen Subtypes and Crosslinks: Application in Minipig Cartilages.Cartilage · 2021Article
- Biomechanical Assessment of the Validity of Sheep as a Preclinical Model for Testing Mandibular Fracture Fixation Devices.Frontiers in bioengineering and biotechnology · 2021Article
- Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Effects of dynamic radial tensile stress on fibrocartilage differentiation of bone marrow mesenchymal stem cells.Biomedical engineering online · 2020Article
- IL-1β Damages Fibrocartilage and Upregulates MMP-13 Expression in Fibrochondrocytes in the Condyle of the Temporomandibular Joint.International journal of molecular sciences · 2019Article
- Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc.Trends in molecular medicine · 2019Review
- Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Frequent involvement of the disc in temporomandibular joint (TMJ) disorders warrants attempts to tissue engineer TMJ disc replacements. Physiologically, a great degree of similarity is seen between humans and farm pigs (FPs), but the pig's rapid growth confers a significant challenge for in vivo experiments. Minipigs have a slower growth rate and are smaller than FPs, but minipig TMJ discs have yet to be fully characterized. The objective of this study was to determine the suitability of the minipig for TMJ studies by extensive structural and functional characterization. The properties of minipig TMJ discs closely reproduced previously reported morphological, biochemical, and biomechanical values of human and FP discs. The width/length dimension ratio of the minipig TMJ disc was 1.95 (1.69 for human and 1.94 for FP). The biochemical evaluation revealed, on average per wet weight, 24.3% collagen (22.8% for human and 24.9% for FP); 0.8% glycosaminoglycan (GAG; 0.5% for human and 0.4% for FP); and 0.03% DNA (0.008% for human and 0.02% for FP). Biomechanical testing revealed, on average, compressive relaxation modulus of 50 kPa (37 kPa for human and 32 kPa for FP), compressive instantaneous modulus of 1121 kPa (1315 kPa for human and 1134 kPa for FP), and coefficient of viscosity of 13 MPa·s (9 MPa·s for human and 3 MPa·s for FP) at 20% strain. These properties also varied topographically in accordance to those of human and FP TMJ discs. Anisotropy, quantified by bidirectional tensile testing and histology, again was analogous among minipig, human, and FP TMJ discs. The minipig TMJ's ginglymoarthrodial nature was verified through cone beam computer tomography. Collectively, the similarities between minipig and human TMJ discs support the use of minipig as a relevant model for TMJ research; considering the practical advantages conferred by its growth rate and size, the minipig may be a preferred model over FP.
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