Evidence map›Paper›PMID 28548551›Full record

ArticleJournal of feline medicine and surgery2018

Comparison of intramuscular butorphanol and buprenorphine combined with dexmedetomidine for sedation in cats.

Rebecca J Bhalla, Toby A Trimble, Elizabeth A Leece, Enzo Vettorato

Open access · greenAbstract readClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Feline procedural sedation and analgesia: When, why and how.Journal of feline medicine and surgery · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebecca J Bhalla1 Anaesthesia Service, Dick White Referrals, Six Mile Bottom, UK.
Toby A Trimble2 Small Animal Hospital, University of Glasgow, Glasgow, UK.
Elizabeth A Leece3 Anaesthesia Service, Northwest Veterinary Specialists, Sutton Weaver, UK.
Enzo Vettorato1 Anaesthesia Service, Dick White Referrals, Six Mile Bottom, UK.
University of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives The objective of this study was to compare the sedative effect of butorphanol-dexmedetomidine with buprenorphine-dexmedetomidine following intramuscular (IM) administration in cats. Methods Using a prospective, randomised, blinded design, 40 client-owned adult cats were assigned to receive IM dexmedetomidine (10 µg/kg) combined with either butorphanol (0.4 mg/kg) ('BUT' group) or buprenorphine (20 µg/kg) ('BUP' group). Sedation was scored using a previously published multidimensional composite scale before administration (T0) and 5, 10, 15 and 20 mins afterwards (T5, T10, T15 and T20, respectively). Alfaxalone (1.5 mg/kg) was administered IM at T20 if the cat was not deemed adequately sedated to place an intravenous catheter. Adverse events were recorded. Friedman two-way ANOVA analysed sedation scores within groups. Mann-Whitney Rank Sum test compared sedation scores between groups; Fisher's exact test analysed the frequency of alfaxalone administration and adverse events. P <0.05 was considered statistically significant. Results Sedation scores between groups were similar at baseline, but at T5, T10, T15 and T20 scores were higher in the BUT group ( P <0.01). Within both groups, sedation scores changed over time and the highest sedation scores were reached at T10. Requirement for additional sedation was similar between groups: two cats in the BUT group and five cats in the BUP group. One cat and 11 cats vomited ( P = 0.002) in the BUT and BUP groups, respectively. No other adverse events were recorded. Conclusions and relevance At these doses, IM buprenorphine-dexmedetomidine provides inferior sedation and a higher incidence of vomiting than butorphanol-dexmedetomidine in cats. Butorphanol-dexmedetomidine may be preferred for feline sedation, especially where vomiting is contraindicated.

Indexed as

AnesthesiaAnimalsBlood PressureBuprenorphineButorphanolCat DiseasesCatsDexmedetomidineDrug Therapy, CombinationFemaleHypnotics and SedativesInjections, IntramuscularMalePain MeasurementProspective StudiesRandom AllocationBuprenorphineButorphanolDexmedetomidineHypnotics and Sedatives

Identifiers

PMID28548551
PMCPMC11129212
OpenAlexW2618210785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.