ArticleBritish journal of pharmacology2017
The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Therapeutic efficacy of LysGH15 against necrotising pneumonia caused byFrontiers in veterinary science · 2025Article
- Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart.Frontiers in pharmacology · 2023Article
- Effects of Enhanced Intracranial Pressure on Blood Pressure and the Cardio-Ankle Vascular Index in Rabbits.Journal of atherosclerosis and thrombosis · 2021Article
- The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes.British journal of pharmacology · 2017Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
background and purposeSeveral rabbit proarrhythmia models have been developed using genetic or pharmacological methods to suppress the slow component of delayed rectifier K EXPERIMENTAL APPROACH: Bradycardia was induced in isoflurane-anaesthetized rabbits by inducing AVB with catheter ablation, and the ventricle was electrically driven at 60 beats min KEY
resultsIn our model, TdP arrhythmias appeared with high reproducibility after i.v. dofetilide (10-100 μg·kg CONCLUSIONS AND IMPLICATIONS: These results suggest that our model of the unremodelled and bradycardic heart of the anaesthetized rabbit is a useful test system for the detection of drug-induced TdP arrhythmias.
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