Evidence map›Paper›PMID 28547678›Full record

ReviewPaediatric drugs2017

Immunosuppression Drug Therapy in Lung Transplantation for Cystic Fibrosis.

Pamela Burcham, Lisa Sarzynski, Sabrina Khalfoun, Kimberly J Novak, Julie C Miller, Dmitry Tumin, Don Hayes

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Paediatric drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Pamela BurchamDepartment of Pharmacy, The Ohio State University, Columbus, OH, USA.
Lisa SarzynskiDepartment of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA.
Sabrina KhalfounDepartment of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA.
Kimberly J NovakSection of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Julie C MillerDepartment of Pharmacy, Nationwide Children's Hospital, Columbus, OH, USA.
Dmitry TuminDepartment of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA.
Don HayesDepartment of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA. hayes.705@osu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic fibrosis (CF) is a common indication for lung transplantation (LTx) in children and adults with severe and irreversible lung disease. In the setting of LTx in the CF population, immunosuppressive medications are used to prevent allograft rejection despite the majority of these patients being chronically infected with numerous, and often antibiotic-resistant, pathogens. There is limited evidence for the optimal post-LTx immunosuppression regimen in patients with CF, particularly in children. This article provides a review of immunosuppression regimens in the pediatric and adult CF post-LTx population, investigating drug dosing and monitoring, and medication combinations. Currently used immunosuppressive medications and related systemic adverse effects are reviewed. With limitations of data in the pediatric population, future research should address immunosuppression in these children to help guide pediatric drug management as a means to optimize clinical outcomes after LTx.

Indexed as

Lung TransplantationAdolescentCystic FibrosisHumansImmunosuppressive AgentsYoung AdultImmunosuppressive Agents

Identifiers

PMID28547678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.