ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2018
Is coronary calcium scoring too late? Total body arterial calcium burden in patients without known CAD and normal MPI.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prognostic Value of Abdominal Aortic Calcification: A Systematic Review and Meta-Analysis of Observational Studies.Journal of the American Heart Association · 2021Pooled it
- Trial
- Predictive nomogram for abdominal aortic calcification risk: a multi-algorithm approach integrating demographic and clinical variables.Journal of cardiothoracic surgery · 2026Article
- Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women.Current atherosclerosis reports · 2026Review
- Quantification of Abdominal Aortic Calcification on CT: Clinical Validation for Assessment Of Cardiovascular Risk in Oncology.Journal of imaging informatics in medicine · 2026Article
- Thoracic aortic calcification as a predictor of coronary artery disease: a systematic review and meta-analysis.Journal of pathology and translational medicine · 2025Article
- Association between life's crucial 9 and severe abdominal aortic calcification in U.S. Adults: the mediating role of the systemic inflammatory response index.Frontiers in endocrinology · 2025Article
- Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014.Journal of health, population, and nutrition · 2024Article
- Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013-2014.BMC cardiovascular disorders · 2024Article
- Aortic calcification correlates with pseudoaneurysm or penetrating aortic ulcer of different etiologies.Scientific reports · 2024Article
- Association between a body shape index and cognitive impairment among US older adults aged 40 years and above from a cross-sectional survey of the NHANES 2011-2014.Frontiers in endocrinology · 2024Article
- Association between dietary niacin intake and abdominal aortic calcification among the US adults: the NHANES 2013-2014.Frontiers in nutrition · 2024Article
- Atherosclerotic plaque burden evaluated from neck to groin: effect of gender and cardiovascular risk factors.The international journal of cardiovascular imaging · 2019Observational
- Use of coronary artery calcium scanning as a triage for invasive coronary angiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2018. Part 1 of 2: Positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Clinical significance of extra-coronary arterial calcifications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
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Authors and funding
15 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with normal myocardial perfusion imaging (MPI) have a good prognosis. However, pre-clinical coronary and extracoronary atherosclerosis may exist in the absence of myocardial ischemia.
methods154 Egyptian patients (mean age 53 years) underwent whole-body non-contrast CT following normal MPI.
resultsAtherosclerosis in the form of calcification was observed in ≥1 vascular bed in 115 of 154 (75%) patients. This included the iliofemoral (62%), abdominal aorta (53%), thoracic aorta (47%), coronary (47%), and carotid (25%) vascular beds. Mean total body calcium score was 3172 ± 530 AU. Extracoronary atherosclerosis in patients with a zero coronary artery calcium (CAC) score was common, occurring in the above-listed beds 42%, 36%, 29%, and 7% of the time, respectively. CAC was rarely present without iliofemoral or abdominal aortic calcification.
conclusionQuantitative assessment of calcification in different vascular beds demonstrates that extracoronary atherosclerosis is common in patients who have normal MPI. Atherosclerotic calcifications are most common in the iliofemoral arteries and abdominal aorta, which typically predate coronary calcifications. An imaging strategy to detect extracoronary atherosclerosis could lead to greater understanding of the natural history of atherosclerosis in its long pre-clinical phase and possibly to earlier preventive strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.