Evidence map›Paper›PMID 28547656›Full record

ArticleBreast cancer research and treatment2017

Influence of clinical, societal, and treatment variables on racial differences in ER-/PR- breast cancer survival.

M E Roseland, K Schwartz, J J Ruterbusch, L Lamerato, R Krajenta, J Booza, Michael S Simon

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Racial Differences in Breast Cancer Survival Between Black and White Women According to Tumor Subtype: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Racial/Ethnic Disparities in Survival after Breast Cancer Diagnosis by Estrogen and Progesterone Receptor Status: A Pooled Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

M E RoselandWayne State University School of Medicine, Detroit, MI, USA.
K SchwartzDepartment of Family Medicine & Public Health Sciences, Wayne State University, Detroit, MI, USA.
J J RuterbuschPopulation Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, 4100 John R HW4HO, Detroit, MI, 48201, USA.
L LameratoDepartment of Public Health Sciences, Henry Ford Health Systems, Detroit, MI, USA.
R KrajentaDepartment of Public Health Sciences, Henry Ford Health Systems, Detroit, MI, USA.
J BoozaDepartment of Family Medicine & Public Health Sciences, Wayne State University, Detroit, MI, USA.
Michael S SimonPopulation Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University, 4100 John R HW4HO, Detroit, MI, 48201, USA. simonm@karmanos.org.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
NCI NIH HHS N01 PC035145NCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

backgroundAfrican American (AA) women with breast cancer have persistently higher mortality compared to whites. We evaluated racial disparities in mortality among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer.

methodsThe study population included 542 women (45% AA) diagnosed with ER/PR-negative Stage I through III breast cancer treated at the Henry Ford Health System (HFHS) between 1996 and 2005. Linked datasets from HFHS, Metropolitan Detroit Cancer Surveillance System, and the U.S. Census Bureau were used to obtain demographic, socioeconomic, and clinical information. Economic deprivation was categorized using a previously validated deprivation index, which included 5 categories based on the quintile of census tract socioeconomic deprivation. Cox proportional hazards models were used to assess the relationship between race and mortality.

resultsAA women were more likely to have larger tumors, have higher Charlson Comorbidity Indices (CCI), and to reside in economically deprived areas. In an unadjusted analysis, AA women demonstrated a significantly higher risk of death compared to whites [hazard ratio (HR) 1.47, 95% confidence interval (CI) 1.09-2.00]. Following adjustment for clinical factors (age, stage, CCI) and treatment (radiation and chemotherapy), AA race continued to have a significant impact on mortality (HR 1.51, CI 1.10-2.08 and HR 1.63, CI 1.20-2.21). Only after adjusting for deprivation was race no longer significant (HR 1.26, CI 0.84-1.87).

conclusionsSocial determinants of health play a large role in explaining racial disparities in breast cancer outcomes, especially among women with aggressive subtypes.

Indexed as

Black or African AmericanWhite PeopleAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsChi-Square DistributionComorbidityDatabases, FactualFemaleHealthcare DisparitiesHumansMichiganMiddle AgedNeoplasm GradingBiomarkers, TumorReceptors, EstrogenReceptors, ProgesteroneAfrican AmericansHormone receptor negative breast cancerRacial disparitiesSocioeconomic statusSurvival

Identifiers

PMID28547656
PMCPMC6849388

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.