ArticleDiabetologia2017
Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01843114 (Measurement of Total Retinal Blood Flow in Patients With Diabetes and Healthy Subjects), which is not on this map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Measurement of Total Retinal Blood Flow in Patients With Diabetes and Healthy Subjects
Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- A New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry.Translational vision science & technology · 2024Trial
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Racial Variations in Retinal Oxygen Metabolic Biomarkers in Diabetic Retinopathy: A Pilot Study.Journal of ophthalmology · 2026Article
- Assessing and monitoring abnormal retinal blood circulation for early detection of pre-structural damage and enhanced diabetic retinopathy staging using non-invasive, high-resolution biophotonic imaging technology.Eye (London, England) · 2025Review
- Ocular Microvascular Changes in Offspring Born to Mothers With Gestational Diabetes Mellitus: The Nanjing Eye Study.Translational vision science & technology · 2025Article
- Association of hemispheric retinal oxygen extraction and macular plexus-specific capillary density in moderate to advanced glaucomatous hemifield defect.Scientific reports · 2025Article
- Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System.Cancer medicine · 2025Article
- Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA.Translational vision science & technology · 2025Article
- Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia.Translational vision science & technology · 2025Observational
- Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy.Scientific reports · 2024Article
- Optical Coherence Tomography Angiography as a Diagnostic Tool for Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2024Review
- Acute uveitic phase of Vogt-Koyanagi-Harada disease: optic nerve head swelling, ocular blood flow and retinal oxygen metabolism.Eye (London, England) · 2023Article
- The accumulated oxygen deficit as an indicator of the ischemic retinal insult.Experimental eye research · 2023Article
- Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry.Communications medicine · 2023Article
- Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia.Translational vision science & technology · 2023Article
- Wide-field swept-source OCTA in the assessment of retinal microvasculature in early-stage diabetic retinopathy.BMC ophthalmology · 2022Observational
- Retinal Oxygen Metabolism in Patients With Type 2 Diabetes and Different Stages of Diabetic Retinopathy.Diabetes · 2022Article
- Retinal oxygen kinetics imaging and analysis (ROKIA) based on the integration and fusion of structural-functional imaging.Biomedical optics express · 2022Article
- Retinal Oxygen Extraction in Patients with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2022Article
- Neuro-vascular coupling and heart rate variability in patients with type II diabetes at different stages of diabetic retinopathy.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to compare retinal oxygen extraction in individuals with diabetes with no or mild non-proliferative diabetic retinopathy and healthy age- and sex-matched volunteers.
methodsA total of 24 participants with type 1 diabetes and 24 healthy age- and sex-matched volunteers were included in this cross-sectional study. Retinal oxygen extraction was measured by combining total retinal blood flow measurements using a custom-built bi-directional Doppler optical coherence tomography system with measurements of oxygen saturation using spectroscopic reflectometry. Based on previously published mathematical modelling, the oxygen content in retinal vessels and total retinal oxygen extraction were calculated.
resultsTotal retinal blood flow was higher in diabetic participants (46.4 ± 7.4 μl/min) than in healthy volunteers (40.4 ± 5.3 μl/min, p = 0.002 between groups). Oxygen content in retinal arteries was comparable between the two groups, but oxygen content in retinal veins was higher in participants with diabetes (0.15 ± 0.02 ml O CONCLUSIONS/
interpretationOur data indicate early retinal hypoxia in individuals with type 1 diabetes with no or mild diabetic retinopathy as compared with healthy control individuals. Further studies are required to fully understand the potential of the technique in risk stratification and treatment monitoring.
trial registrationClinicalTrials.gov NCT01843114.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.