Evidence map›Paper›PMID 28547117›Full record

ArticleJournal of gastrointestinal cancer2018

Non-Hypervascular Hypointense Nodules at Gadoxetic Acid MRI: Hepatocellular Carcinoma Risk Assessment with Emphasis on the Role of Diffusion-Weighted Imaging.

Chiara Briani, Marco Di Pietropaolo, Massimo Marignani, Francesco Carbonetti, Paola Begini, Vincenzo David, Elsa Iannicelli

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Article in Journal of gastrointestinal cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chiara BrianiRadiology Unit, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy. chiara.briani@uniroma1.it.
Marco Di PietropaoloRadiology Unit, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Massimo MarignaniDepartment of Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Francesco CarbonettiRadiology Unit, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Paola BeginiDepartment of Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Vincenzo DavidRadiology Unit, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Elsa IannicelliRadiology Unit, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

aimIn cirrhotic patients, the characterization of hypovascular nodules, hypointense on hepatobiliary phase gadoxetic acid disodium-enhanced magnetic resonance images (Gd-EOB-DTPA-enhanced MRI), is essential to look for the proper approach strategy. Our objective was to evaluate the imaging features and risk assessment of hypovascular nodules, hypointense on Gd-EOB-DTPA-enhanced MRI, focusing on the diagnostic value of diffusion-weighted imaging (DWI). MATERIAL AND

methodsThis prospective study includes 35 patients with 50 hypovascular hypointense nodules. Signal intensity on T2-weighted images and DWI, vascular pattern on dynamic contrast-enhanced MRI and on hepatobiliary phase, and volume doubling time were analyzed for each nodule as well as patient's clinical features. Univariate and multivariate analyses were made to determine the variables associated with the development of hypervascular pattern.

resultsOn 24 months follow-up period, 40% of the hypointense nodules (mean size 14 mm ± 6.1) became hypervascular hepatocellular carcinoma (HCC) with 6 and 12 months cumulative risk of 45 and 55%. Nine/12 (75%, mean size 15.50 mm ± 7.2) that appeared hyperintense in DWI at first exam show malignant transformation (p value = 0.007). Univariate and multivariate analyses identified hyperintensity at initial DWI (OR 6.49; 95% CI 1.28-32.80; p value = 0.009) and size ≥10 mm (OR 6.22; 95% CI 1.57-24.63; p value = 0.024) as independent factors with the development of HCC.

conclusionIn conclusion, hypovascular lesions ≥10 mm and those hyperintense in DWI were associated with progression to hypervascular HCC. A close follow-up or histological characterization is recommended to improve patients outcome and to develop effective treatment.

Indexed as

Contrast MediaDiffusion Magnetic Resonance ImagingGadolinium DTPAAgedCarcinoma, HepatocellularChronic DiseaseDisease ProgressionFemaleHumansLiverLiver DiseasesLiver NeoplasmsMaleMiddle AgedNeovascularization, PathologicProspective StudiesContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPADiffusion-weighted imagingHepatocarcinogenesisHepatocellular carcinomaLiver cirrhosisMR imaging

Identifiers

PMID28547117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.