ReviewBurns & trauma2017
Current progress in understanding the molecular pathogenesis of burn scar contracture.
Review in Burns & trauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Adipose-Derived Stem Cells as Therapeutic Approach in Hypertrophic Scar Formation-A Systematic Review.International wound journal · 2026Pooled it
- Correction of cicatricial ectropion using non-ablative fractional laser resurfacing.Lasers in medical science · 2019Trial
- Research Advances in Therapeutic Strategies and Drug Delivery Systems for Pathological Scars.Pharmaceutics · 2026Review
- Case Report: Scar contracture caused by ruptured subcutaneous ganglion cyst misdiagnosed as Dupuytren's disease: diagnostic reflections on a rare case.Frontiers in surgery · 2026Article
- Strengthening rehabilitation to reduce burn contractures and disability in sub Saharan Africa.Frontiers in rehabilitation sciences · 2026Article
- Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Effect of negative pressure therapy on the treatment response to scar thickness and viscoelasticity.Frontiers in bioengineering and biotechnology · 2024Article
- Nano drug delivery systems: a promising approach to scar prevention and treatment.Journal of nanobiotechnology · 2023Review
- 3D-Printed Functional Hydrogel by DNA-Induced Biomineralization for Accelerated Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Lipoaspirate fluid derived factors and extracellular vesicles accelerate wound healing in a rat burn model.Frontiers in bioengineering and biotechnology · 2023Article
- Down-Regulating Scar Formation by Microneedles DirectlyACS nano · 2022Article
- Modern Aspects of Burn Injury Immunopathogenesis and Prognostic Immunobiochemical Markers (Mini-Review).Biotech (Basel (Switzerland)) · 2022Review
- Skin Grafting Using Collagen Fiber Orientation Matching.Plastic and reconstructive surgery. Global open · 2022Article
- Skin biomechanics: a potential therapeutic intervention target to reduce scarring.Burns & trauma · 2022Review
- Integrated spatial analysis of gene mutation and gene expression for understanding tumor diversity in formalin-fixed paraffin-embedded lung adenocarcinoma.Frontiers in oncology · 2022Article
- Article
- A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns.Burns & trauma · 2021Review
- Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography.Cell adhesion & migration · 2019Article
- Article
- Toward understanding scarless skin wound healing and pathological scarring.F1000Research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal wound healing is likely to induce scar formation, leading to dysfunction, deformity, and psychological trauma in burn patients. Despite the advancement of medical care treatment, scar contracture in burn patients remains a challenge. Myofibroblasts play a key role in scar contracture. It has been demonstrated that myofibroblasts, as well as inflammatory cells, fibroblasts, endothelial cells, and epithelial cells, secrete transforming growth factor-β1 (TGF-β1) and other cytokines, which can promote persistent myofibroblast activation via a positive regulation loop. In addition to the cellular contribution, the microenvironments, including the mechanical tension and integrin family, are also involved in scar contracture. Most recently, eukaryotic initiation factor 6 (eIF6), an upstream regulator of TGF-β1, has been demonstrated to be involved in myofibroblast differentiation and contraction in both in vitro fibroblast-populated collagen lattice (FPCL) and in vivo external mechanical stretch models. Moreover, the data showed that P311 could induce the transdifferentiation of epidermal stem cells to myofibroblasts by upregulating TGF-β1 expression, which mediated myofibroblast contraction. In this review, we briefly described the most current progress on the biological function of myofibroblasts in scar contracture and subsequently summarized the molecular events that initiated contracture. This would help us better understand the molecular basis of scar contracture as well as to find a comprehensive strategy for preventing/managing scar contracture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.