Evidence map›Paper›PMID 28546857›Full record

ArticleCell & bioscience2017

Chloroquine inhibits Ca

Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell & bioscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. The contrasting effects of two antimalarial drugs on insulin secretion.Cellular and molecular life sciences : CMLS · 2025
    Article
  3. Article
  4. Chloroquine inhibits artificial oocyte activation induced by ethanol or SrThe Journal of reproduction and development · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. COVID-19 as an Acute Inflammatory Disease.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yi-Fan Wu *Institute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Ping Zhao *Institute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Xi Luo *Institute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Jin-Chao XuInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Lu XueInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Qi ZhouInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Mingrui XiongInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Jinhua ShenInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Yong-Bo PengInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Meng-Fei YuInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Weiwei ChenInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Liqun MaInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
Qing-Hua LiuInstitute for Medical Biology & Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South Central University for Nationalities, Wuhan, 430074 China.
South Central University for Nationalities · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChloroquine, a bitter tastant, inhibits Ca

resultsIn this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca

conclusionsThese results indicate that chloroquine inhibits Ca

Indexed as

B cellsCa2+ChloroquineIP3RSTIM/Orai channelsTRPC3 channels

Identifiers

PMID28546857
PMCPMC5442594
OpenAlexW2618432800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.