Evidence map›Paper›PMID 28546750›Full record

ReviewNeuropsychiatric disease and treatment2017

Biomarkers for depression: recent insights, current challenges and future prospects.

Rebecca Strawbridge, Allan H Young, Anthony J Cleare

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 178 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06138301 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Digital Interventions for Social isOLation In youThs And theIR familiEs

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Integrata VeronaRan2023 to 2025Enrolled80ConditionsSocial Isolation, Psychosocial ProblemArmsCognitive Behavioral Therapy (CBT), Cognitive Remediation (CR)
NCT06901739 narecruitingnot on this mapstarted 2025, after this paper: background citation

New Dietary Intervention Strategies on the Intestinal Microbiota to Improve Mental Health Subjects With Obesity: Therapeutic Potential of a Synbiotic.

TypeinterventionalSponsorCelia BañulsRan2025 to 2027Enrolled120ConditionsObese Patients (BMI ≥ 30 kg/m²), Anxiety, Depressive DisorderArmsSynbiotic, Placebo
NCT06994988 recruitingnot on this mapstarted 2026, after this paper: background citation

Multi-modal Smart Band-Aid for AI-based Quantification of Pain

TypeobservationalSponsorNorthwestern UniversityRan2026 to 2027Enrolled115ConditionsChronic PainArmsA-Band (Smart Band-Aid), Empatica Smartwatch, Questionnaires: Hospital Anxiety & Depression Scale, Central Sensitization Inventory, Pain Catastrophizing Scale, Somatic Symptom Scale-8, Pain Self-Efficacy Questionnaire-10, Athens Insomnia Scale
3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  13. Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rebecca StrawbridgeCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London.
Allan H YoungCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London.
Anthony J CleareCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London.

Funding

Wellcome Trust
6 · The paper itself

Abstract

A plethora of research has implicated hundreds of putative biomarkers for depression, but has not yet fully elucidated their roles in depressive illness or established what is abnormal in which patients and how biologic information can be used to enhance diagnosis, treatment and prognosis. This lack of progress is partially due to the nature and heterogeneity of depression, in conjunction with methodological heterogeneity within the research literature and the large array of biomarkers with potential, the expression of which often varies according to many factors. We review the available literature, which indicates that markers involved in inflammatory, neurotrophic and metabolic processes, as well as neurotransmitter and neuroendocrine system components, represent highly promising candidates. These may be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomic and neuroimaging assessments. The use of novel approaches and systematic research programs is now required to determine whether, and which, biomarkers can be used to predict response to treatment, stratify patients to specific treatments and develop targets for new interventions. We conclude that there is much promise for reducing the burden of depression through further developing and expanding these research avenues.

Indexed as

inflammationmajor depressive disordermood disorderpersonalized medicinestratificationtreatment response

Identifiers

PMID28546750
PMCPMC5436791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.